杀菌/通透性增加蛋白研究进展

›› 2009, Vol. 36 ›› Issue (11): 41-43.

杀菌/通透性增加蛋白研究进展

肖晶¹，李晓莉^1,2，童亮¹，李彦兵¹，袿祎¹，李进涛¹，张以芳¹

(1.云南农业大学动物科学技术学院，昆明 650201； 2.中国水产科学研究院长江水产研究所，荆州 434000)

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-11-20 发布日期:2009-11-20
通讯作者: 张以芳

Study Progress in Bactericidal/Permeability Increasing Protein

XIAO Jing¹, LI Xiao-li^1,2, TONG Liang¹, LI Yan-bing¹, GUI Yi¹, LI Jin-tao¹, ZHANG Yi-fang¹

(1.Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China;2.Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Jingzhou 434000, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-11-20 Published:2009-11-20
Contact: ZHANG Yi-fang

摘要/Abstract

摘要： 杀菌/通透性增加蛋白(bactericidal permeability increasing protein, BPI)是一种主要存在于中性粒细胞内的阳离子抗菌蛋白，具有杀菌及中和内毒素作用，在革兰氏阴性菌感染的治疗方面有很好的应用前景。作者主要对BPI分子结构、生物学功能、作用机制及应用前景等方面进行综述。

关键词: 杀菌/通透性增加蛋白; 革兰氏阴性菌; 内毒素

Abstract: The bactericidal/ permeability increasing protein (BPI), a cationic antibacterial and endotoxin-neutralizing activity protein located in neutrophilic granulocytes has a good prospect in clinical treatment of Gram-negative infections. The molecule structure, biological function, functional mechanisms and clinical research of BPI are summarized in this review.

Key words: bactericidal/permeability increasing protein; Gram negative bacteria; endotoxin

中图分类号:

S852.4⁺4

肖晶;李晓莉;童亮;李彦兵;袿祎;李进涛;张以芳. 杀菌/通透性增加蛋白研究进展[J]. , 2009, 36(11): 41-43.

XIAO Jing;LI Xiao-li;TONG Liang;LI Yan-bing;GUI Yi;LI Jin-tao;ZHANG Yi-fang. Study Progress in Bactericidal/Permeability Increasing Protein[J]. , 2009, 36(11): 41-43.

[1]	康苏, 夏丽洁, 刘军, 马纪, 张富春. 新疆家蚕抗菌肽可有效抑制掌面革兰氏阴性菌的研究[J]. 中国畜牧兽医, 2014, 41(9): 239-244.
[2]	李彦兵;桂祎;李进涛;李作生;史宪伟;张以芳. 杀菌/通透性增加蛋白研究现状及应用前景[J]. , 2009, 36(9): 29-33.