中国畜牧兽医 ›› 2024, Vol. 51 ›› Issue (7): 3206-3214.doi: 10.16431/j.cnki.1671-7236.2024.07.044

• 临床兽医 • 上一篇    

舒泰复合右美托咪定两种给药方案对巴马小型猪麻醉效果观察

李俊锋1, 陈冬妮1, 窦心怡1, 侯晓昱1, 朴雪1, 赵元1, 杨天元1, 杨昊天2, 范宏刚1   

  1. 1. 东北农业大学动物医学学院, 哈尔滨 150030;
    2. 黑龙江省农业科学院畜牧兽医分院, 齐齐哈尔 161005
  • 收稿日期:2023-11-28 发布日期:2024-07-03
  • 通讯作者: 范宏刚 E-mail:fanhonggang2002@163.com
  • 作者简介:李俊锋,E-mail:aulijunfeng@163.com。
  • 基金资助:
    国家自然科学基金面上项目(32273078)

Observation on the Anesthetic Effect of Two Administration Regimens of Zoletil Combined with Dexmedetomidine on Bama Miniature Pig

LI Junfeng1, CHEN Dongni1, DOU Xinyi1, HOU Xiaoyu1, PIAO Xue1, ZHAO Yuan1, YANG Tianyuan1, YANG Haotian2, FAN Honggang1   

  1. 1. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China;
    2. Animal Husbandry and Veterinary Branch of Heilongjiang Academy of Agricultural Sciences, Qiqihar 161005, China
  • Received:2023-11-28 Published:2024-07-03

摘要: 【目的】探究不同舒泰复合右美托咪定给药方案对巴马小型猪麻醉效果的影响。【方法】将8头巴马小型猪随机均分为静脉注射(IV)组和肌内注射(IM)组,麻醉间隔期为14 d。IV组耳缘静脉注射舒泰3.3 mg/kg+右美托咪定8 μg/kg;IM组耳后颈部肌内注射舒泰4.6 mg/kg+右美托咪定11.2 μg/kg。在麻醉过程中对巴马小型猪的麻醉时期、麻醉效果、生理指标及生物反射进行监测。【结果】IV组麻醉诱导时间、维持时间、苏醒时间分别为3.75、85.75和30.25 min。IM组麻醉诱导时间、维持时间、苏醒时间分别为7.13、107.00和41.00 min。IV和IM组分别可维持50和65 min外科麻醉期。IM组80~110 min时麻醉效果评分显著高于IV组(P<0.05)。麻醉过程中两种方案的体温(T)下降,心率(HR)和血氧饱和度(SpO2)先降低后升高,呼吸频率(RR)、收缩压(SBP)、舒展压(DBP)和平均动脉压(MAP)先升高后降低。IM组50~80 min时RR显著高于IV组(P<0.05)。IM组10~15 min时SBP显著低于IV组(P<0.05)。IV和IM组生物反射完全抑制时间分别为45和50 min。【结论】舒泰复合右美托咪定对巴马小型猪麻醉效果良好,诱导迅速,维持时间长,苏醒平稳,对巴马小型猪生理指标和生物反射影响较小,其中IM组麻醉方案比IV组更适合临床外科手术和科研教学使用。

关键词: 巴马小型猪; 舒泰; 右美托咪定; 复合麻醉; 给药方案

Abstract: 【Objective】 This experiment was aimed to explore the effect of different zoletil combined with dexmedetomidine on the anesthetic effect of Bama miniature pigs.【Method】 Eight Bama miniature pigs were randomly divided into intravenous injection (IV) group and intramuscular injection (IM) group,and the anesthesia interval was 14 days.Group IV received zoletil 3.3 mg/kg+dexmedetomidine 8 μg/kg intravenously at the ear edge.In group IM,zoletil 4.6 mg/kg+dexmedetomidine 11.2 μg/kg was injected into the muscles of the neck behind the ear.The period of anesthesia,anesthetic effect,biological reflex and physiological indexes of Bama miniature pigs were monitored during anesthesia.【Result】 The results showed that the induction time,maintenance time and recovery time of anesthesia in group IV were 3.75,85.75 and 30.25 min,respectively.The induction time,maintenance time and recovery time of anesthesia in group IM were 7.13,107.00 and 41.00 min,respectively.Groups IV and IM could maintain surgical anesthesia for 50 and 65 min,respectively.The anesthesia effect score in group IM was significantly higher than that in group IV during 80-110 min (P<0.05).During anesthesia,body temperature decreased.Heart rate and blood oxygen saturation decreased first and then increased.Respiratory rate,systolic pressure,stretch pressure and mean arterial pressure increased first and then decreased.Respiratory rate in group IM was significantly higher than that in group IV during 50-80 min (P<0.05).The systolic blood pressure in group IM was lower than that in group IV during 10-15 min (P<0.05).The total inhibition time of biological reflex in groups IV and IM were 45 and 50 min,respectively.【Conclusion】 Zoletil combined with dexmedetomidine had a good anesthesia effect on Bama miniature pigs,with rapid induction,long maintenance time,stable recovery,and minimal impact on physiological indicators and biological reflexes.Among them,group IM anesthesia plan was more suitable for clinical surgery and scientific research teaching than group IV.

Key words: Bama miniature pig; zoletil; dexmedetomidine; combined anesthesia; administration regimen

中图分类号: