铜绿假单胞菌生物膜研究进展

doi:10.16431/j.cnki.1671-7236.2016.11.025

摘要/Abstract

摘要：

条件致病菌铜绿假单胞菌（PA）是一种能形成生物膜的革兰氏阴性菌，作者综述了PA生物膜形成的生物学机制，包括菌体黏附、胞外多糖Psl和Pel、藻朊酸盐等参与细菌生物膜成熟的过程及群体感应系统调节相关因子表达，从而调控细菌形成生物膜应对不良环境。此外还概括了将生物膜作为靶点开发的药物等生物膜相关的研究进展。生物膜是菌体逃避有害刺激的护盾，研究其结构、形成及致病机理，了解PA产生耐药性的分子机制，对于通过调节生物膜形成或调控生物膜相关因子的表达进而优化PA的抗感染治疗有十分重要的意义。

关键词: 铜绿假单胞菌; 生物膜; 群体感应系统

Abstract:

The opportunistic pathogen Pseudomonas aeruginosa is a gram-negative bacteria which can form biofilms.In this review,we summarized the biology mechanism of biofilms in Pseudomonas aeruginosa,including Pseudomonas aeruginosa adhesion,extracellular polysaccharide Psl and Pel,alginate participated in the biofilm maturation,and quorum sensing systems regulated the formation of biofilm in Pseudomonas aeruginosa,and the drug target on biofilm.The bacterial biofilms protected the bacteria from unsuitable environmental conditions.Through researching the structure and the pathogenesis of Pseudomonas aeruginosa,and its resistance molecular mechanisms,we could adjust or regulate the expression of biofilm-associated factors,optimize the anti-infection treatment in Pseudomonas aeruginosa.

Key words: Pseudomonas aeruginosa; biofilms; quoring sensing system

中图分类号:

R378.99⁺1

孟菲, 黎书长, 杨武宁, 刘伟, 银慧慧, 韦晓洁, 姜源明, 赵武, 覃振华, 孙建华. 铜绿假单胞菌生物膜研究进展[J]. 《中国畜牧兽医》, 2016, 43(11): 2976-2981.

MENG Fei, LI Shu-chang, YANG Wu-ning, LIU Wei, YIN Hui-hui, WEI Xiao-jie, JIANG Yuan-ming, ZHAO Wu, QIN Zhen-hua, SUN Jian-hua. Research Progress on Biofilms in Pseudomonas aeruginosa[J]. , 2016, 43(11): 2976-2981.

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