[1] Kobayashi M,Itoh K,Suzuki T,et al.Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system[J].Genes Cells,2002,7(8):807-820.
[2] Itoh K,Wakabayashi N,Katoh Y,et al.Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain[J].Genes Dev Gene Dev,1999,13(1):76-86.
[3] Donna D Z.Mechanistic studies of the Nrf2-Keap1 signaling pathway[J].Drug Metab Rev,2006,38(4):769-789.
[4] 童海达,王佳茗,宋英.Keap1-Nrf2-ARE在机体氧化应激损伤中的防御作用[J].癌变·畸变·突变,2013,1:71-75.
[5] Wakabayashi N,Itoh K,Takahashi S.Keap1 mutation leads to postnatal lethality due to constitutive Nrf2 activation[J].Nat Genet,2003,35(3):238-245.
[6] 梁明振,杨炳壮,苏安伟,等.水牛奶营养价值评价[J].广西畜牧兽医,2007,3:124-126.
[7] 肖开田,张世生,李跃民.水牛繁殖生物技术研究进展[J].动物医学进展,2005,3:10-12.
[8] 庄利利,胡德宝,蔡丽娟,等.哺乳动物胚胎的活性氧来源及其抗氧化机制[J].中国畜牧兽医,2013,40(3):173-176.
[9] Dinkova-Kostova A T,Holtzclaw W D,Cole R N,et al.Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants[J].P Natl Acad Sci USA,2002,99(18):11908-11913.
[10] 刘芳,杜志银,王应雄.Keap1在氧化应激方面的研究进展[J].中国临床药理学与治疗学,2010,5:596-600.
[11] Kansanen E,Jyrkkänen H K,Levonen A L.Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids[J].Free Radical Biology & Medicine,2012,52(6):973-982.
[12] Kensler T,Wakabayashi N S.Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway[J].Annual Review of Pharmacology,2007,47:89-116.
[13] Hideaki K,Yoshihisa N,Takeshi M,et al.PDX-1/VP16 fusion protein,together with NeuroD or Ngn3,markedly induces insulin gene transcription and ameliorates glucose tolerance[J].Diabetes,2005,54(4):1009-1022.
[14] Kwak J J,Tirumani S H,Van den Abbeele A D,et al.Cancer immunotherapy:Imaging assessment of novel treatment response patterns and immune-related adverse events[J].Radiographics,2015,35(2):424-437.
[15] Xu C,Huang M G,Yuan X,et al.Inhibition of 7,12-dimethylbenz(a) anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2[J].Cancer Res,2006,66(16):8293-8296.
[16] Copple I M.The Keap1-Nrf2 cell defense pathway——A promising therapeutic target[J].Advances in Pharmacology,2012,63:43-79.
[17] Ishikawa M,Numazawa S,Yoshida T.Redox regulation of the transcriptional repressor Bach1[J].Free Radical Bio Med,2005,38(10):1344-1352.
[18] Maher J,Yamamoto M.The rise of antioxidant signaling——The evolution and hormetic actions of Nrf2[J].Toxicol Appl Pharm,2010,244(1):4-15.
[19] Zhang D D,Lo S C,Cross J V,et al.Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex[J].Mol Cell Biol,2004,24(24):10941-10953.
[20] Shibata T,Ohta T,Tong K I,et al.Cancer related mutations in NRF2 impairits recognition by Keap1-Cul3 E3 ligaseand promote malignancy[J].PNAS,2008,105(36):13568-13573.
[21] Kim S K,Yang J W,Kim M R,et al.Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells[J].Free Radical Bio Med,2008,45(4):537-546. |