繁殖毒理学研究进展

doi:10.16431/j.cnki.1671-7236.2016.03.023

›› 2016, Vol. 43 ›› Issue (3): 714-719.doi: 10.16431/j.cnki.1671-7236.2016.03.023

繁殖毒理学研究进展

赵晓乐, 孔晓军, 李世宏, 秦哲, 刘希望, 杨亚军, 李剑勇

中国农业科学院兰州畜牧与兽药研究所兽药重点实验室, 农业部兽用药物创制重点实验室, 甘肃省新兽药工程重点实验室, 兰州 730050

收稿日期:2015-09-08 出版日期:2016-03-20 发布日期:2016-03-30
通讯作者: 李剑勇 E-mail:lijy1971@163.com
作者简介:赵晓乐(1989-),女,河北邢台人,硕士,研究方向,药物繁殖毒性,E-mail:xiaole_1920@163.com
基金资助:
国家自然基金项目(31572573)

Research Progress on Reproductive Toxicology

ZHAO Xiao-le, KONG Xiao-jun, LI Shi-hong, QIN Zhe, LIU Xi-wang, YANG Ya-jun, LI Jian-yong

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Science, CAAS, Lanzhou 730050, China

Received:2015-09-08 Online:2016-03-20 Published:2016-03-30

摘要/Abstract

摘要： 随着现代生物科学研究的不断深入,产科学、药理学和毒理学相互交叉渗透,使得繁殖毒理学逐渐发展起来。繁殖毒理学包括生殖毒理学和发育毒理学,是探究环境、药物等因素对亲代的生殖功能及子代发育过程是否有影响的一门科学。本文就繁殖毒理学所探讨的受试物对试验动物的生殖细胞发生、卵细胞受精、胚胎形成、妊娠、分娩、哺乳过程及初生幼仔发育的损害作用等进行综述。

关键词: 生殖毒性; 发育毒性; 新技术

Abstract: With the deepening of modern biological science,obstetrics,pharmacology and toxicology intersect penetration with each other,thus gradually make the development of reproductive toxicology.Reproductive toxicology include two parts:Reproductive toxicology and developmental toxicology,it is a method focused on exploring whether there are influences of environmental and drugs factors on parental reproductive functions and the development of offspring.In this paper,the injury effects of test drugs on the reproductive cytogenesis,fertilization of egg cell,embryogenesis,pregnancy,childbirth,breast-feeding and development of newborn pups were summarized.

Key words: reproductive toxicity; developmental toxicity; new technology

中图分类号:

赵晓乐, 孔晓军, 李世宏, 秦哲, 刘希望, 杨亚军, 李剑勇. 繁殖毒理学研究进展[J]. , 2016, 43(3): 714-719.

ZHAO Xiao-le, KONG Xiao-jun, LI Shi-hong, QIN Zhe, LIU Xi-wang, YANG Ya-jun, LI Jian-yong. Research Progress on Reproductive Toxicology[J]. , 2016, 43(3): 714-719.

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繁殖毒理学研究进展

Research Progress on Reproductive Toxicology

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