环氧二十碳三烯酸生物学作用机制的研究进展

doi:10.16431/j.cnki.1671-7236.2016.03.021

›› 2016, Vol. 43 ›› Issue (3): 700-706.doi: 10.16431/j.cnki.1671-7236.2016.03.021

环氧二十碳三烯酸生物学作用机制的研究进展

何静¹, 乌云额尔敦¹, 吉日木图¹, 玉斯日古楞²

1. 内蒙古农业大学食品工程学院, 乳品生物技术与工程教育部重点实验室, 呼和浩特 010018;
2. 内蒙古农业大学兽医学院, 农业部动物疾病临床诊疗技术重点实验室, 呼和浩特 010018

收稿日期:2015-10-08 出版日期:2016-03-20 发布日期:2016-03-30
通讯作者: 玉斯日古楞 E-mail:srgl_imau@163.com
作者简介:何静(1990-),女,内蒙古巴彦淖尔人,硕士生,研究方向:乳制品生物技术,E-mail:hejing1409@163.com
基金资助:
国家自然科学基金项目(31360598);内蒙古自然科学基金项目(2013MS0412)

Research Progress on Biological Mechanism of Epoxyeicosatrienoic Acids

HE Jing¹, Wuyuneerdun¹, Jirimutu¹, Yusiriguleng²

1. Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China;
2. Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2015-10-08 Online:2016-03-20 Published:2016-03-30

摘要/Abstract

摘要： 花生四烯酸经过细胞色素P450 (cytochrome P450,CYP)表氧化酶途径生成环氧二十碳三烯酸(epoxyeicosatrienoic acids,EETs)。EETs可以通过调节离子通道和基因表达,从而发挥促进血管舒张、抗炎和细胞增殖等作用。EETs也可通过激活信号转导途径和调节基因表达或与细胞膜受体结合发挥多种生物学功能。EETs也可快速与细胞膜磷脂结合后以共吸收的方式被细胞摄取。文章主要从EETs的来源、去路、作用机制等方面进行讨论。

关键词: 环氧二十碳三烯酸; 膜受体; 离子通道; 胞内机制

Abstract: Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by cytochrome P450 epoxygenases.They modulate ion transport and gene expression,producing vasorelaxation as well as antiinflammatory and cell proliferation effects.Many of the functional effects of EETs occur through activation of signal transduction pathways and modulation of gene expression,events probably initiated by binding to a putative cell surface EETs receptor.However,EETs are rapidly taken up by cells and are incorporated into and released from phospholipids,it suggests that some functional effects may occur through a direct interaction between the EETs and an intracellular effector system.EETs synthesis,metabolism,mechanism of action are reviewed in this paper.

Key words: epoxyeicosatrienoic acids; cell surface receptor; ion transport; intracellular mechanism

中图分类号:

何静, 乌云额尔敦, 吉日木图, 玉斯日古楞. 环氧二十碳三烯酸生物学作用机制的研究进展[J]. , 2016, 43(3): 700-706.

HE Jing, Wuyuneerdun, Jirimutu, Yusiriguleng. Research Progress on Biological Mechanism of Epoxyeicosatrienoic Acids[J]. , 2016, 43(3): 700-706.

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环氧二十碳三烯酸生物学作用机制的研究进展

Research Progress on Biological Mechanism of Epoxyeicosatrienoic Acids

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