嗅觉与味觉对动物采食作用研究进展

doi:10.16431/j.cnki.1671-7236.2015.12.018

摘要/Abstract

摘要： 良好的采食行为是动物机体维持生长发育和提高生产性能的基础,而嗅觉和味觉是动物采食过程中最重要的两种感官感受,它们分别由嗅觉受体和味觉受体基因决定,这些受体基因家族是哺乳动物基因组中较大的基因家族,不仅在感觉器官中表达,还广泛表达于呼吸、消化、生殖等系统中。作者对中国羊肉消费和羊的饲养情况,当前嗅觉、味觉及其受体基因的最新研究进展,嗅觉和味觉在动物采食中的作用和机制,以及嗅觉和味觉在畜禽养殖中的应用进行了综述,为研究嗅觉和味觉在动物采食尤其是羊上的作用提供参考。

关键词: 采食; 嗅觉; 味觉; 受体基因; 饲养; 羊

Abstract: Good food intake behavior is the basis of maintaining the growth and development of animal and improving production performance.Olfaction and taste are two important senses in the progress of animal food intake.They are determined by olfactory receptor genes and taste receptor genes respectively,which are relatively large gene family in mammalian genomes.They express not only in the sense organs,but also widely in the respiratory,digestive,reproductive and other systems.This paper analyzed the consumption of mutton and sheep breeding in China.It gave an overview of the latest research progress on the olfaction,taste and their receptor gene.Finally,the function and mechanism of olfaction and taste in animal food intake,and the utilization in livestock production were expounded.This paper provided a theoretical reference for the study of the sense of olfaction and taste in animal food feeding especially in sheep.

Key words: food intake; olfactory; taste; receptor gene; breeding; sheep

中图分类号:

Q434

轩俊丽, 张莉, 杜立新. 嗅觉与味觉对动物采食作用研究进展[J]. , 2015, 42(12): 3231-3238.

XUAN Jun-li, ZHANG Li, DU Li-xin. Research Progress on Effects of Olfactory and Taste on Animal Food Intake[J]. , 2015, 42(12): 3231-3238.

参考文献

[1] 聂绪明,何明发,杜贵贤.猪嗅觉在规模养殖场的临床应用[J].畜禽业,2006,11:33-34.
[2] 高一龙,缪勤,张汇东,等.嗅觉受体基因的研究进展[J].遗传,2010,32(1):17-24.
[3] Mombaerts P.Seven-transmembrane proteins as odorant and chemosensory receptors[J].Science,1999,286(5440):707-711.
[4] Fuchs T,Glusman G,Horn-Saban S,et al.The human olfactory subgenome:From sequence to structure and evolution[J].Human Genetics,2001,108(1):1-13.
[5] Mombaerts P.Molecular biology of odorant receptors in vertebrates[J].Annu Rev Neuro Sci,1999,22:487-509.
[6] Buck L,Axel R.A novel multigene family may encode odorant receptors:A molecular basis for odor recognition[J].Cell,1991,65(1):175-187.
[7] Serizawa S,Miyamichi K,Sakano H.One neuron-one receptor rule in the mouse olfactory system[J].Trends in Genetics,2004,20(12):648-653.
[8] Serizawa S,Miyamichi K,Sakano H.Negative feedback regulation ensures the one neuron-one receptor rule in the mouse olfactory system[J].Chemical Senses,2005,30(1):i99-i100.
[9] Michaloski J S,Galante P A,Malnic B.Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences[J].Genome Research,2006,16(9):1091-1098.
[10] Tobar H F,Moreno P A,Vélez P E.Highly conserved regions in the 5'region of human olfactory receptor genes[J].Genetics and Molecular Research,2009,8(1):117-128.
[11] Niimura Y,Nei M.Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates[J].J Hum Genet,2006,51(6):505-517.
[12] Niimura Y.Evolutionary dynamics of olfactory receptor genes in chordates:Interaction between environments and genomic contents[J].Hum Genomics,2009,4(2):107-118.
[13] Glusman G,Yanai L,Rubin L,et al.The complete human olfactory subgenome[J].Genome Res,2001,11(5):685-702.
[14] Olender T,Fuchs T,Linhart C,et al.The canine olfactory subgenome[J].Genomics,2004,83(3):361-372.
[15] Zhang X,Firestein S.The olfactory receptor gene superfamily of the mouse[J].Nat Neurosci,2002,5(2):124-133.
[16] Nguyen D T,Lee K,Choi H,et al.The complete swine olfactory subgenome:Expansion of the olfactory gene repertoire in the pig genome[J].BMC Genomics,2012,13:584.
[17] Niimura Y,Nei M.Extensive gains and losses of olfactory receptor genes in mammalian evolution[J].PLoS One,2007,2(8):e708.
[18] Lai P C,Bahl G,Gremigni M,et al.An olfactory receptor pseudogene whose function emerged in humans:A case study in the evolution of structure-function in GPCRs[J].Journal of Structural and Functional Genomics,2008,9(1-4):29-40.
[19] 魏永详,韩德民.嗅觉研究现状[J].中国医学文摘耳鼻咽喉科学,2007,22(4):214-215.
[20] Goto T,Salpekar A,Monk M.Expression of a testis-specific member of the olfactory receptor gene family in human primordial germ cells[J].Molecular Human Reproduction,2001,7(6):553-558.
[21] Feingold E A,Penny L A,Nienhuis A W,et al.An olfactory receptor gene is located in the extended human β-globin gene cluster and is expressed in erythroid cells[J].Genomics,1999,61(1):15-23.
[22] Yuan T T,Toy P,McClary J A,et al.Cloning and genetic characterization of an evolut ionarily conserved human olfactory receptor that is different ially expressed across species[J].Gene,2001,278(1-2):41-51.
[23] Spehr M,Schwane K,Riffell J A,et al.Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm[J].Molecular and Cellular Endocrinology,2006,250(1-2):128-136.
[24] Roura1 E,Baldwin M W,Klasing K C.禽类味觉系统研究进展[J].中国家禽,2012,34(12):44-47.
[25] 张根华,邓少平.味觉受体第一家族与味觉识别[J].生命的化学,2005,3:179-181.
[26] Chandrashekar J,Mueller K L,Hoon M A,et al.T2Rs function as bitter taste receptors[J].Cell,2000,100(6):703-711.
[27] Margolskee R F.Molecular mechanisms of bitter and sweet taste transduction[J].Journal of Biological Chemistry,2002,277(1):1-4.
[28] Bufe B,Breslin P A,Kuhn C,et al.The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception[J].Curr Biol,2005,15(4):322-327.
[29] Spehr M,Gisselmann G,Poplawski A,et al.Identification of a testicular odorant receptor mediating human sperm chemotaxis[J].Science,2003,299(5615):2054-2058.
[30] Ishimaru Y,Inada H,Kubota M,et al.Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor[J].Proc Natl Acad Sci USA,2006,103(33):12569-12574.
[31] Chaudhari N,Landin A M,Roper S D.A metabotropic glutamate receptor variant functions as a taste receptor[J].Nat Neurosci,2000,3(2):113-119.
[32] 张奎启.味觉研究的进展[J].国外医学·口腔医学分册,1984,2:68-74.
[33] Singh N,Vrontakis M,Parkinson F,et al.Functional bitter taste receptors are expressed in brain cells[J].Biochemical and Biophysical Research Communications,2011,406(1):146-151.
[34] Misior A M,Deshpande D A,Loza M J,et al.Glucocorticoid-and protein kinase A-dependent transcriptome regulation in airway smooth muscle[J].American Journal of Respiratory Cell and Molecular Biology,2009,41(1):24-39.
[35] 陈晓慧,张春雷,陈宏,等.哺乳类动物胃肠道内味觉受体的信号研究[J].中国牛业科学,2012,38(5):49-52.
[36] Taniguchi K.Expression of the sweet receptor protein,T1R3,in the human liver and pancreas[J].Anatomy,2004,66(11):1311-1314.
[37] Elliott R A,Kapoor S,Tincello D G.Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders[J].The Journal of Urology,2011,186(6):2455-2462.
[38] Treesukosol Y,Smith K R,Spector A C.The functional role of the T1R family of receptors in sweet taste and feeding[J].Physiology & Behavior,2011,105(1):14-26.
[39] Meyer D,Voigt A,Widmayer P,et al.Expression of Tas1 taste receptors in mammalian spermatozoa:Functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa[J].PLoS One,2012,7(2):e32354.
[40] Li F,Zhou M.Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice[J].Molecular Human Reproduction,2012,18(6):289-297.
[41] Xu J,Cao J,Iguchi N,et al.Functional characterization of bitter-taste receptors expressed in mammalian testis[J].Molecular Human Reproduction,2012,19(1):17-28.
[42] Shah A S,Ben-Shahar Y,Moninger T O,et al.Motile cilia of human airway epithelia are chemosensory[J].Science,2009,325(5944):1131-1134.
[43] Tizzano M,Gulbransen B D,Vandenbeuch A,et al.Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals[J].Proceedings of the National Academy of Sciences,2010,107 (7):3210-3215.
[44] Deshpande D A,Wang W C,McIlmoyle E L,et al.Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction[J].Nature Medicine,2010,16(11):1299-1304.
[45] Margolskee R F,Dyer J,Kokrashvili Z,et al.T1R3 and gustducin in gut sense sugars to regulate expression of Na⁺-glucose cotransporter1[J].PNAS,2007,104(38):15075-15080.
[46] Spehr M,Schwane K,Riffell J A,et al.Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm[J].Molecular and Cellular Endocrinology,2006,250(1-2):128-136.
[47] Chamorro C A,de Paz P,Fernández J G,et al.Fungiform papillae of the pig and the wild boar analyzed by scanning electron microscopy[J].Scanning Microsc,1993,1(7):313-320.
[48] Kudo K,Shiraishi J,Nishimura S,et al.The number of taste buds is related to bitter taste sensitivity in layer and broiler chickens[J].Animal Science Journal,2010,81(2):240-244.
[49] Shi P,Zhang J.Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes[J].Molecular Biology and Evolution,2005,23(2):292-300.
[50] Go Y,Satta Y,Takenaka O,et al.Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates[J].Genetics,2005,170(1):313-326.
[51] Go Y.Lineage-specific expansions and contractions of the bitter taste receptor gene repertoire in vertebrates[J].Molecular Biology and Evolution,2006,23(5):964-972.
[52] Fischer A,Gilad Y,Man O,et al.Evolution of bitter taste receptors in humans and apes[J].Molecular Biology and Evolution,2004,22(3):432-436.
[53] Zhou Y,Dong D,Zhang S,et al.Positive selection drives the evolution of bat bitter taste receptor genes[J].Biochemical Genetics,2009,47(3-4):207-215.
[54] Duffy V B,Miller I J,Bartoshuk L M.6-n Propylthiouracil (PROP) super tasters and women have greater number of fungiform papillae taste buds[J].Chem Senses,1994,19:465.
[55] Bartoshuk L M,Duffy V B,Reed D,et al.Supertasting,earaches and head injury:Genetics and pathology alter our taste worlds[J].Neuroscience and Biobehavioral Reviews,1996,20(1):79-87.
[56] Bromley S M.Smell and taste disorders:A primary care approach[J].Am Fam Physician,2000,61(2):427-438.
[57] 赖文清,汪静雯.影响采食量的因素[J].国外畜牧学-猪与禽,2004,24(4):13-18.
[58] 田宗祥,张玲清.高温对猪采食量的影响机制及应用的研究进展[J].中国畜牧兽医,2011,38(3):228-230.
[59] 董凌云,雒秋江,潘超,等.饲喂颗粒日粮对妊娠母羊采食和消化代谢的影响[J].中国畜牧兽医,2014,41(6):77-83.
[60] 龙瑞军,董世魁,王元素,等.反刍动物采食量的概念与研究方法[J].草业学报,2003,12(5):8-17.
[61] 刘靖,张石蕊.猪采食量的调控[J].营养与饲料,2009,2:54-59.
[62] Rozengurt E,Sternini C.Taste receptor signaling in the mammalian gut[J].Current Opinion in Pharmacology,2007,7(6):557-562.
[63] Rozengurt N,Wu S V,Chen M C,et al.Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon[J].AJP:Gastrointestinal and Liver Physiology,2006,291(5):G792-G802.
[64] Zufall F,MungerS D.Receptor guanylyl cyclases in mammalian olfactory function[J].Mol Cell Biochem,2010,334(1-2):191-197.
[65] Lesniak A,Walczak M,Jezierski T,et al.Canine olfactory receptor gene polymorphism and its relation to odor detection performance by sniffer dogs[J].Journal of Heredity,2008,99(5):518-527.
[66] Robin S,Tacher S,Rimbault M,et al.Genetic diversity of canine olfactory receptors[J].BMC Genomics,2009,10(1):21.
[67] 张敏,魏书磊,刘振辉.哺乳动物的味觉受体及其介导的信号途径研究进展[J].鲁东大学学报(自然科学版),2012,28(2):160-166.
[68] Vegezzi G,Anselmi L,Huynh J,et al.Diet-induced regulationof bitter taste receptor subtypes in the mouse gastrointestinal tract[J].PLoS One,2014,9(9):e107732.
[69] Zhang C L,Yuan J,Wang Q,et al.The association of bovine T1R family of receptors polymorphisms with cattle growth traits[J].Research in Veterinary Science,2012,93(2):783-787.
[70] Dotson C D,Zhang L,Xu H,et al.Bitter taste receptors influence glucose homeostasis[J].PLoS One,2008,12(3):e3974.
[71] Kaji I,Karaki S,Fukami Y,et al.Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors,T2Rs,in thehuman and rat large intestine[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2009,296(5):G971-G981.
[72] 陈守云.猪采食调控机制研究进展[J].中国畜牧兽医,2011,38(9):24-29.
[73] 于继英,黄美珍.畜禽采食量的调节[J].中国畜牧兽医,2005,32(9):6-8.
[74] 金立志,倪冬娇,高增兵.动物采食生理特点及采食量调控技术研究的新进展[J].饲料广角,2005,5:3-7.
[75] 李欣,田树军,赵国先,等.不同风味诱食剂对羔羊采食行为和生产性能的影响[J].中国饲料,2013,23:32-34.
[76] Moran A W,Al-Rammahi M,Zhang C,et al.Sweet taste receptor expression in ruminant intestine and itsactivation by artificial sweeteners to regulate glucose absorption[J].Journal of Dairy Science,2014,97(8):4955-4972.
[77] Ferreira A M,Araújo S S,Sales-Baptista E,et al.Identification of novel genes for bitter taste receptors insheep[J].Animal,2013,7(4):547-554.