nesfatin-1抑制摄食的作用及其机制研究进展

doi:10.16431/j.cnki.1671-7236.2015.08.020

摘要/Abstract

摘要： nesfatin-1是最近研究发现的一种新的厌食分子。其前体蛋白核连蛋白2 (NUCB2)水解形成3个片段:nesfatin-1、nesfatin-2和nesfatin-3。nesfatin-1的中间片段(M30)具有强烈的抑制摄食的作用,nesfatin-2和nesfatin-3不抑制摄食且其生物学功能目前尚不清楚。此外,nesfatin-1还参与行为、情绪、生殖、睡眠、癫痫和糖尿病等的调控。作者综述了nesfatin-1的发现、命名、结构、分布、主要的生物学功能及其抑制摄食的机制。

关键词: nesfatin-1; 核连蛋白2; 摄食; 厌食

Abstract: The recently discovered nesfatin-1 is a new anorexigenic molecule.The precursor protein nucleobindin-2 (NUCB2) is proteolytically cleaved into three fragments, nesfatin-1, nesfatin-2 and nesfatin-3.The middle segment of nesfatin-1 (M30) is responsible for inhibiting food intake, while the physiological role of nesfatin-2 and nesfatin-3 are not currently known yet.nesfatin-1 plays roles in behaviour, mood, reproduction, sleeping, epilepsy and diabetic hyperphagia.We reviewed the discovery, designation, biochemical structure, distribution, its main biological function and the possible mechanism of inhibiting food intake effect of nesfatin-1.

Key words: nesfatin-1; NUCB2; food intake; anorexigenic

中图分类号:

R589.2

谢光美, 林方军. nesfatin-1抑制摄食的作用及其机制研究进展[J]. , 2015, 42(8): 2058-2065.

XIE Guang-mei, LIN Fang-jun. Research Progress on Effect and Mechanism of nesfatin-1 on Inhibiting Food Intake[J]. , 2015, 42(8): 2058-2065.

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