›› 2014, Vol. 41 ›› Issue (11): 242-246.

Previous Articles     Next Articles

Evaluation of Efficacy of Rhizoma Dryopteris Crassirhizomae Soluble Powder against Artificial Infection with Infectious Bursal Disease Virus

ZHANG Qiang1, LI Ming-zhe2, YANG Zong-rang3, SHI Ning-ning1, YANG Qun-hui1, WEN Peng-cheng1, HE Cheng1   

  1. 1. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;
    2. Korean Huishan Agriculture and Forestry University, Huishan HS001, Korea;
    3. Baoji Chencang Animal Husbandry Bureau, Baoji 721300, China
  • Received:2014-04-02 Online:2014-11-20 Published:2014-12-06

Abstract: The present study was aimed to determine the efficacy of Rhizoma Dryopteris Crassirhizomae (RDC) soluble powder in artificial infection with infectious bursal disease virus (IBDV). Firstly, SPF chicken were inoculated with the IBDV LX strain in order to induce virus infectious model, and then the chicken of high,middle,low 3 groups were administered orally with 198, 99 and 50 mg/kg RDC soluble powder while the chicken were administered with Korean RDC oral solution or Astragalus polysaccharide for 5 days as the control group. Meanwhile, chicken inoculated with IBDV and without IBDV were regarded as the infectious control and healthy control groups. Body weight gain, cure rate, survival rate and immune organ index were employed to determine the efficacies. After experimental infection with IBDV, an extremely significant increase of body weight gain was found in the RDC soluble powder middle and low dose groups compared to Korean RDC group (P<0.01).RDC soluble powder low dose group was significantly higher than RDC soluber powder middle dose group and Astragalus polysacharide group (P<0.05), however, no significant difference was found between RDC soluble powder middle dose group and Astragalus polysaccharide group (P>0.05). With respect to the survival rate, 80% chicken recovered from IBDV infection in the RDC soluble powder high,middle,low dose groups, which were significantly higher compared to Korean RDC group (66.7%) and Astragalus polysaccharide group (53.3%) (P<0.05). In terms of immune organ index, the significant increase of thymus and spleens indexes was found in RDC soluble powder middle and low does groups compared to that of the infectious control group (P<0.05). However, no significant difference of bursal index was found among RDC soluble powder high,middle and low dose groups, Korean RDC group and Astragalus polysaccharide group (P>0.05).In summary, chicken administered orally with 50 mg/kg RDC soluble powder for 5 days would contribute to the immune activation by improvement of thymus and spleen indexes, leading to high survival rate against the artificially challenge with IBDV. With respect to survival rate and recovery protection, it was higher than that of Astragalus polysaccharide.

Key words: Rhizoma Dryopteris Crassirhizomae soluble powder; Korean Rhizoma Dryopteris Crassirhizomae; infectious bursal disease; efficacy; chicken

CLC Number: