猪链球菌多样性及其致病因子研究进展

Abstract

Abstract: Streptococcus suis (SS) is a major porcine pathogen and also is an important pathogen that can be transmitted to human beings by close contact with sick or carrier pigs. In July 2005, the largest outbreak of human SS infection occurred in Sichuan province, China. After that, more researches on this pathogen had been carried out over the world. Serotype 2 was the most popular one in pathogenic SS. Although the most research was carried out on it, still limited knowledge was known of its virulent factors and causitive agent. The target of this paper is to provide the newest research progress reports of this pathogen and mainly of its virulent factors.

Key words: Streptococcus suis; diversity; virulent factors

HUAN Hai-xia, HUANG Li-li, ZHANG Ke. Advance on Diversity and Virulent Factors of Streptococcus suis[J]. China Animal Husbandry & Veterinary Medicine.

References

1 马玉玲，陆承平，范红结. 溶原性噬菌体在猪链球菌2型分离株中的检出和鉴定[J]. 微生物学报，2008, 48(4)：508～513.
2 尹国友，孙婕，陈兰英，等. 猪链球菌2型分离株精氨酸脱亚氨酸酶遗传变异分析[J]. 中国畜牧兽医，2011, 38(5)：117～120.
3 鞠爱萍. 苏中地区猪链球菌分子流行病学调查及猪链球菌2型反应调控因子RevS缺失株的构建[D]. 南京：南京农业大学，2007.
4 Arends J P, Zanen H C. Meningitis caused by Streptococcus suis in humans[J]. Rev Infect Dis, 1988(10): 131～137.
5 Baums C G, Kaim U, Fulde M, et al. Identification of a novel virulence determinant with serum opacification activity in Streptococcus suis[J]. Infect Immun, 2006(74): 6154～6162.
6 Beaudoin M, Harel J, Higgins R, et al. Molecular analysis of isolates of Streptococcus suis capsular type 2 by restriction-endonuclease-digested DNA separated on SDS-PAGE and by hybridization with an rDNA probe[J]. Gen Microbiol, 1992(138): 2639～2645.
7 Berthelot-Herault F, Gottschalk M, Labbe A, et al. Experimental airborne transmission of Streptococcus suis capsular type 2 in pigs[J]. Veterinary Microbiology, 2001(82): 69～80.
8 Bonifait L, De La Cruz D M, Vaillancourt K, et al. The cell envelope subtilisin-like proteinase is a virulence determ inant for Streptococcus suis[J].BMC Microbiol, 2010, 10(1): 42.
9 Chen C, Tang J, Dong W, et al． A glimpse of streptococcal toxic shock syndrome from comparative genomics of S.suis 2 Chinese isolates[J]．PLoS One, 2007, 2(3): 315.
10 Chen H, Liao H, Wang C, et al. Construction and in vitro assay of the sortase BCD geneknock-out mutant of Streptococcus suis[J]. Acta Microbiologica Sinica, 2011, 51(3): 386～392.
11 de Greeff A, Buys H, Verhaar R, et al. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2[J]. Infect Immun, 2002a, 70(3): 1319～1325.
12 de Greeff A, Buys H, van Alphen L, et al．Response regulator important in pathogenesis of Streptococcus suis serotype 2[J]. Microb Pathog, 2002b, 33(4): 185～192.
13 Feng Y, Cao M, Shi J, et al. Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture[J]. Sci Rep, 2012(2): 710.
14 Fittipaldi N, Sekizaki T, Takamatsu D, et al. D-alanylation of lipoteichoic acidcontributes to the virulence of Streptococcus suis[J]. Infect Immun, 2008a, 76(8): 3587～3594.
15 Fittipaldi N, Sekizaki T, Takamatsu D, et al. Significant contribution of the pgdA gene to the virulence of Streptococcus suis[J]. Mol Microbiol, 2008b, 70(5): 1120～1135.
16 Gottschalk M, Segura M, Xu J. Streptococcus suis infections in humans: The Chinese experience and the situationin North America[J]. Anim Healt Res Rev, 2007(8): 29～45.
17 Graham M R, Smoot L M, Migliaccio C A, et al. Virulence control in group A Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modeling[J]. Proc Natl Acad Sci USA, 2002, 99(21): 13855～13860.
18 Harel J, Martinez G, Nassar A, et al. Identification of an inducible bacteriophage in a virulent strain of Streptococcus suis serotype 2[J]. Infect Immun, 2003, 71(10): 6104.
19 Higgins R, Gottschalk M，Mittal K R, et al. Streptococcus suis infection in swine. A sixteen month study[J]. Can J Vet Res, 1990, 54(1): 170～173.
20 Hill J E, Gottschalk M, Brousseau R, et al. Biochemical an alysis, cpn60 and 16S rDNA sequence data indicate that Streptococcus suis serotypes 32 and 34, isolated from pigs, are Streptococcus orisratti[J]. Vet Microbiol, 2005(107): 63～69.
21 Hu Q, Liu P, Yu Z, et al. Identification of a cell wall-associated subtilisin-like serine protease involved in the pathogenesis of Streptococcus suis serotype 2[J]. Microbial pathogenesis, 2010, 48(3): 103～109.
22 Jobin M C, Brassard J, Quessy S, et al. Acquisition of host plasmin activity by the swine pathogen Streptococcus suis serotype 2[J]. Infect Immun, 2004(72): 606～610.
23 Li J, Tan C, Zhou Y, et al. The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2[J]. Vet Microbiol, 2011, 148(1): 99～104.
24 Li M, Wang C, Feng Y, et al. SalK/SalR, a two-component signal transduction system, is essential for fullvirulence of highly invasive Streptococcus suis serotype 2[J]. PLoS One, 2008(3): 2080.
25 Li W, Wan Y, Tao Z, et al. A novel fibronectin-binding protein of Streptococcus suis serotype 2 contributes to epithelial cell invasion and in vivo dissemination[J]. Vet Microbiol, 2012, 162(1): 186～194.
26 Lu Q, Lu H, Qi J, et al. An octamer of enolase from Streptococcus suis[J]. Protein Cell, 2012, 3(10): 769～780.
27 Okwumabua O, Persaud J S, Reddy P G. Cloning and characterization of the gene encoding the glutamate dehydrogenase of Streptococcus suis serotype 2[J]. Clinical and Diagnostic Laboratory Immunology, 2001, 8(2): 251～257.
28 Seele J, Singpiel A, Spoerry C, et al. Identification of a novel host-specific IgM protease in Streptococcus suis[J]. Journal of Bacteriology, 2013, 195(5): 930～940.
29 Smith H E, Vecht U, Wisselink H J, et al. Mutants of Streptococcus suis types 1 and 2 impaired in expression of muramidase-released protein and extracellular protein induce disease innewborn germfree pigs[J]. Infect Immun, 1996(64): 4409～4412.
30 Smith H E, Rijnsburger M, Stockhofe-Zurwieden N, et al. Virulent strains of Streptococcus suis serotype 2 and highly virulent strains of Streptococcus suis serotype 1 can be recognized by a unique ribotype profile[J]. Clin Microbiol, 1997(35): 1049～1053.
31 Smith H E, Veenbergen V, van der Velde J, et al. The cps genes of Streptococcus suis serotypes 1, 2, and 9: Development of rapid serotype-specific PCR assays[J]. Clin Microbiol, 1999(7): 3146～3152.
32 Smith H E, Buijs H, Wisselink H J, et al. Selection of virulence-associated determinants of Streptococcus suis serotype 2 by in vivo complementation[J]. Infect Immun, 2001, 69(3): 1961～1966.
33 Takamatsu D, Nishino H, Ishiji T, et al. Genetic organization and preferential distribution of putative pilus gene clusters in Streptococcus suis[J]. Vet Microbiol, 2009(138): 132～139.
34 Tang Y, Wu W, Zhang X, et al. Catabolite control protein a of Streptococcus suis type 2 contributes to sugar metabolism and virulence[J]. Microbiol, 2012, 50(6): 994～1002.
35 Vanier G, Sekizaki T, Domínguez-Punaro M C, et al. Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins[J]. Vet Microbiol, 2008(27): 417～424.
36 Wang C, Li M, Feng Y, et al. The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2[J]. Arch Microbiol, 2009(191): 23～33.
37 Winterhoff N, Goethe R, Gruening R, et al. Identification and characterization of two temperature induced surface associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes[J]. Bacteriology, 2002, 184(24): 6768～6776.
38 Wisselink H J, Smith H E, Stockhofe-Zurwieden N, et al. Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries[J]. Vet Microbiol, 2000(74): 237～248.
39 Zhang A, Mu X, Chen B, et al. Identification and characterization of IgA1 protease from Streptococcus suis[J]. Veterinary Microbiology, 2010(140): 171～175.
40 Zhang A, Chen B, Yuan Z, et al. HP0197 contributes to CPS synthesis and the virulence of Streptococcus suis via CcpA[J]. PLoS One, 2012, 7(11): e50987.
41 Zhang C P, Ning Y B, Zhang Z Q, et al. Distributions of pathogenic capsular typesand in vitro antimicrobial susceptibility of different serotypes of Streptococcus suis isolated from clinically healthy sows from 10 provinces in China[J]. Zhonghua Liu Xing Bing Xue Za Zhi, 2009(30): 235～238.

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