穿心莲提取物对1～42日龄宁都黄鸡生长性能、血清生化指标及肠道健康的影响

doi:10.16431/j.cnki.1671-7236.2025.05.016

Abstract

Abstract: 【Objective】 This study aimed to evaluate the effects of dietary supplementation with Andrographis paniculata extract (APE) on the growth performance,serum biochemistry and gut health of Ningdu Yellow chickens.【Method】 A total of 270 healthy 1-day-old Ningdu Yellow chickens with similar body weights were randomly assigned to three groups,each with six replicates of 15 chickens.The chickens in APE group were received a basal diet supplemented with 0.1% APE,the chickens in antibiotic control group were given a basal diet with 0.2% chlortetracycline,and the chickens in blank control group were fed a basal diet without additives.The experimental period lasted 42 days.At the ending of the experiment,the body weight and feed intake of Ningdu Yellow chickens were counted to determine the growth performance.Blood samples were collected to determine the serum biochemical indexes.The jejunum tissues and cecal contents were collected to determine intestinal morphological indexes and cecal microbiota structure indexes.【Result】 ①Compared with blank control group,the chickens in APE group exhibited significantly higher final body weight and average daily gain (ADG) (P＜0.05) and a significantly lower feed-to-gain ratio (F/G) (P＜0.05).②Compared with blank control group, the chickens in APE group had significantly higher levels of serum total protein(TP) and albumin(ALB) (P＜0.05). Compared with blank control and antibiotic control groups, the chickens in APE group had significantly higher levels of interleukin-10 (IL-10) (P＜0.05), while the levels of low-density lipoprotein (LDL), triglycerides (TG), IL-1β, IL-6, and tumor necrosisfactor-α (TNF-α), and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly lower (P＜0.05).③The chickens in APE group had a significantly reduced crypt depth (CD) in jejunum compared with blank control group (P＜0.05).The villus height-to-crypt depth (VH/CD) ratio of chickens in APE group was significantly higher than that in antibiotic control and blank control groups (P＜0.05).④Beta diversity analysis revealed significant differences in cecalmicrobial communities among three groups (P＜0.05).Compared with blank control group,the chickens in APE group showed a significant reduction in the relative abundance of Spirochaetes and Deferribacteres (P＜0.05),while the relative abundance of the Rikenellaceae-RC9 gut group increased,which was significantly higher than that in antibiotic control group (P＜0.05).Additionally,the chickens in APE group exhibited a significantly lower relative abundance of Firmicutes and Coprobacillus and a higher abundance of Bacteroidetes compared with blank control group (P＜0.05).【Conclusion】 Dietary APE supplementation improved the growth performance of Ningdu Yellow chickens,reduced blood lipid levels and serum inflammatory markers,enhanced intestinal morphology,and regulated gutmicrobiota structure,thereby promoting better gut health.

Key words: Andrographis paniculata extract; Ningdu Yellow chickens; growth performance; serum biochemistries; intestinal morphology; intestinal microflora

CLC Number:

S816.7

ZHONG Min, YANG Xiaopei, LIU Ruiping, SONG Wenjing, ZHONG Yunping. Effect of Dietary Andrographis paniculata Extract Supplementation on the Growth Performance,Serum Biochemistries,and Gut Health in Ningdu Yellow Chickens[J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(5): 2115-2127.

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Effect of Dietary Andrographis paniculata Extract Supplementation on the Growth Performance,Serum Biochemistries,and Gut Health in Ningdu Yellow Chickens

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