China Animal Husbandry and Veterinary Medicine ›› 2024, Vol. 51 ›› Issue (2): 790-798.doi: 10.16431/j.cnki.1671-7236.2024.02.035

• Preventive Veterinary Medicine • Previous Articles     Next Articles

Research Progress on Regulation of Parasitic Infections by Regulatory B Cells

FENG Anni, LI Qilong, ZHANG Yiwei, SANG Xiaoyu, CHEN Ran, FENG Ying, JIANG Ning   

  1. College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
  • Received:2023-07-05 Online:2024-02-05 Published:2024-01-29
  • Contact: 国家自然科学基金面上项目(31972702);中国医学科学院人兽共患寄生虫致病机制研究创新单元(2019-IM-5-042)

Abstract: Parasitic diseases are infectious diseases that are widespread throughout the world and pose a serious threat to human and animal health.Parasites activate the body’s immune system when they invade the host.The host fights the parasitic infection through innate and acquired immune responses and protects itself from an excessive immune response through a variety of regulatory mechanisms.Regulatory B cells (Bregs) are a subset of B cells with immunosuppressive functions during parasitic infections.They have been more extensively studied in autoimmune diseases, cancer and allergic reactions.Currently, an increasing number of studies have shown that parasitic infections can induce the production of Bregs, and that Bregs can inhibit the inflammatory response by secreting the anti-inflammatory cytokine interleukin-10 (IL-10), thus reducing the damage of parasitic infections to the host.However, the signaling pathways and activation mechanisms of Breg proliferation are still unclear and require further investigation.In this review, the author briefly described the different types of Bregs and their phenotypes, and summarized the immunomodulatory roles of Bregs during Plasmodium, Schistosoma, Leishmania, Toxoplasma and Trypanosoma infections, with the aim of providing new insights into parasite treatment and prevention strategies.

Key words: parasites; immunomodulation; regulatory B cells

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