Abstract: The gastrointestinal tract of animals is regarded as an important barrier against external pathogens,and the health of gastrointestinal tract is inseparable from the health of animal organism.The gastrointestinal tract of animals is inhabited by a large and diverse microbial population,the interactions between microorganisms are complex and diverse,and the function and species composition of microorganisms affect the homeostatic balance of gastrointestinal tract.By colonizing the gastrointestinal mucosa,the microbiota plays a crucial role in the development of mucosal immune system,it also plays an important role in the health and function of gastrointestinal tract.There are many ways to regulate the health of gastrointestinal tract,and at present,the main way to regulate the function of gastrointestinal tract and maintain the health of gastrointestinal tract is by adding non-nutrients and nutritional regulators such as prebiotics and probiotics.However,immunoglobulin regulation of gastrointestinal tract has received less attention compared to other nutritional regulators,is a new immunomodulation technology,which has the advantages of specificity and selectivity,easy and low-cost production,and significant effects.Immunomodulation is an efficient and relatively safe modality of regulation.The author introduces the main physicochemical properties of four immunoglobulins (IgG,IgA,IgY and nanobodies),synthesizes the current research on the regulation of gastrointestinal tract functions by immunoglobulins and provides a prospect for future development,so as to provide guidance for the application of immunoglobulins to regulate gastrointestinal tract health and promote nutrient metabolism in animals.

Key words: immunoglobulin; animals; gastrointestinal tract; functional metabolism; health