水生生物Nrf2-Keap1/Are信号通路的研究进展

doi:10.16431/j.cnki.1671-7236.2021.02.011

Abstract

Abstract: Oxidative stress refers to a kind of stress response in which the oxidation/antioxidation dynamic balance is destroyed due to the increase of active oxygen (ROS) in the body from the stimulation of the external environment.Under normal conditions,the system involved in the production and removal of ROS in the animal body is in a state of dynamic equilibrium.Oxidative stress occurs when ROS production increases or its scavenging capacity decreases due to external environmental stimulation or changes in the body itself.Long-term or excessively strong oxidative stress will result in slowing growth,reducing immune function,occurrence of diseases of aquatic organisms and other hazards,as well as the decline of aquatic product quality and nutritional value.Then,it brings serious economic loss to the aquaculture industy.The Nrf2-Keap1/Are signaling pathway plays a crucial role in resisting exogenous or endogenous oxidative stress.This signaling pathway has been extensively studied in mammals,but hasn't yet seen a systematic review in aquatic organisms.Based on a large number of literatures,from aspects of the mechanism of oxidative stress,the molecular basis of Nrf2 and Keap1,the Nrf2-Keap1/Are signaling pathway,the related research progress of this signaling pathway in aquatic organisms was introduced in this paper,such as fish,shrimp and crab,etc.This paper will provide theoretical parameters and relevant data for the mechanism research of an-oxidative stress in aquatic organisms.

Key words: oxidative stress; nuclear factor E2 related factor 2; Kelch-like ECH-related protein; aquatic organism

CLC Number:

S917.4

YAO Qi, ZHENG Nan, GUO Zhixin, CHEN Yuke, LIU Hongjian, ZHANG Dongming, XU Yongping, WANG Qiuju. Advances in the Nrf2-Keap1/Are Signaling Pathway in Aquatic Organism[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(2): 492-500.

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Advances in the Nrf2-Keap1/Are Signaling Pathway in Aquatic Organism

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