Abstract: Pouring different dosages of APS（0.4, 0.2, 0.1 mg/ml）to exhausted swimming mice’s stomach, we analysed blood component and tested the activities of SOD, GSHPx, CAT. The results showed that the time to swim to exhaust in the highdose group was extremely remarkably prolonged (P<0.01), and that in the middle dose group was significantly prolonged(P<0.05); the total number of WBC, Gran% in the highdose group were significantly lower than those in the control group (P<0.01), Lym%, Mid% and Gran were very significantly higher than those in the control group (P<0.01), the concentration of HGB and HCT in the highdose group and sinodose group were very significantly higher than those in the control group (P<0.01); Lym% and Mid% in the sinodose group were significantly higher than those in the control group (P<0.05); the activity of SOD and CAT were significantly increased in the highdose group and the activity of GSHPX was very significant decreased (P<0.01); the activity of SOD in the sinodose group was significantly increased (P<0.05);the activity of AST and CK in the highdose group and sinodose group were very significantly decreased (P<0.01).Thus, APS has obvious oxidative damage effects.

Key words: APS; exhausted swimming mice; physiological and biochemical indexes