噬菌体抗肺炎克雷伯菌感染及其临床应用的研究进展

doi:10.16431/j.cnki.1671-7236.2025.06.047

Abstract

Abstract: Klebsiella pneumoniae (KP) is a significant zoonotic pathogen that can cause various infections,impacting the health of both humans and animals.The widespread spread of multidrug-resistant KP and the spread of highly virulent KP (hvKP) have aroused great concern for KP infection.Antibiotics are a crucial means to combat KP infection,but the emergence of antimicrobial resistance (AMR) and the exacerbation of multidrug resistance have rendered antibiotic treatment insufficient to meet clinical needs.Phage therapy has attracted much attention due to its unique antibacterial mechanism.Studies have shown that phage can effectively fight KP infection.However,relevant reports mainly focus on pre-clinical in vivo and in vitro trials and a few clinical cases,and lack systematic safety evaluation and application guidance.The author summarized the existing research data from domestic and international studies,systematically reviewed the preclinical studies and clinical case reports of phage against KP infection,aiming to provide reference for the development of phage therapy against KP infection.

Key words: Klebsiella pneumoniae (KP); phage; anti-infection; clinical application

CLC Number:

S852.61⁺2

ZHANG Yuying, XING Jiabao, ZHANG Yichao, ZHANG Hang, ZHANG Junkai, ZHAI Yajun, ZHAO Jinxin, WU Hua. Research Progress on Phage Against Klebsiella pneumoniae Infection and Clinical Application[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2955-2964.

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Research Progress on Phage Against Klebsiella pneumoniae Infection and Clinical Application

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