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Effects of Lyophilized Royal Jelly on Antioxidant Abilities in Aged Mice Induced by D-galactose

CHEN Yan-zhen   

  1. (College of Life ScienceShandong University of TechnologyZibo 255049China)

  • Received:2013-09-27 Online:2014-05-20 Published:2014-06-25

Abstract: To investigate the effects of lyophilized royal jelly (LRZ) on antioxidant abilities in aged mice induced by D-galactose. The subacute aged model mice were made by neck back subcutaneous injection of D-galactose continually. The mice were given three different doses of LRZ, 170, 340, 510 mg/kg,respectively, the effect of LRZ on the content of catalase (CAT), malondialdehyde (MDA), superoxide dismutase (SOD) in serum, liver and brain were observed after 49 d. The CAT, SOD activities in aged model group were significantly decreased (P<0.05), but MDA was significantly increased as compared to normal mice (P<0.05). While in the aged mice treated with LRZ 340 and 510 mg/(kg·bw), the activity of CAT and SOD were significantly increased and the content of MDA significantly decreased as compared to aged mice (P<0.05). LRZ had antioxidant effect in aged mice and showed dose-and-effect relationship.

Key words:

lyophilized royal jelly; antioxidant effect; catalase; malondialdehyde; superoxide dismutase