Abstract: To investigate the anti-inflammatory effect of traditional Chinese medicine compound gongyanjing injection on acute inflammation in mice, we induced mouse ear swelling by xylene,induced mouse toe swelling by egg white,induced peritoneal capillary permeability in mice by glacial acetic acid and cotton pellet induced granuloma and then studied the anti-inflammatory effects in four acute inflammation models.The results showed that the traditional Chinese medicine compound gongyanjing injection could significantly reduce the mice auricle swelling ratio and decrease abdominal capillary permeability of mice （P＜0.05）; and could significantly inhibit the growth of granulation tissue and toe swelling rate （P＜0.05）; the anti-inflammatory effect of high dose group was the most significant, and had no significant difference with the dexamethasone group (P＞0.05). Therefore, the anti-inflammatory effect of traditional Chinese medicine compound gongyanjing injection was significant.

Key words: traditional Chinese medicine compound; gongyanjing injection; anti-inflammatory effect