抗生长激素受体单克隆抗体的功能特点

Abstract

Abstract: The growth hormone receptor (GHR) is the key regulator of postnatal growth which belongs to the type Ⅰ cytokine receptor that mediates many functions regulated by growth hormone (GH). Monoclonal antibodies (mAb) to the GHR have been important tools for the study of this receptor. All these anti-GHR mAbs, designated 1H2, 1A9, 2C3 and mAb263, are highly reactive with GHR, but 1A9 does not promote growth in hypophysectomized rats, 2C3 can do and this effect will be inhibited in the presence of GH. mAb263 as the commercial monoclonal antibody that binding to the receptor has a similar effect with GH, not only can recognise GHR，but also can induce a conformational change of the receptor in a similar manner, but not identical with GH.

Key words: growth hormone receptor; growth hormone; monoclonal antibody; domain 1

YANG Yan-hong，FU Zhi-ling，LIU Yu，LAN Hai-nan，ZHANG Hui，WU Min，MA Si-hui,LI Yu-meng，LI Yan-qiang, ZHENG Xin. Functional Characterization of Anti-growth Hormone Receptor Monoclonal Antibody[J]. .

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Functional Characterization of Anti-growth Hormone Receptor Monoclonal Antibody

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