1 李维. 猪生长激素模拟肽作用机制的研究[D]. 长春:吉林农业大学,2013. 2 杨艳红, 付志玲,兰海楠,等. 生长激素激活受体机理的研究进展[J]. 中国畜牧兽医,2013,40(10):148~151. 3 姒健敏,高敏,曹倩,等. 生长激素及其受体在萎缩性胃炎中的表达及临床意义探讨[J]. 中国消化杂志,2012,8(22):499. 4 Alves dos Santos C M, ten Broeke T, Strous G J. Growth hormone receptor ubiquitination, endocytosis and degradation are independent of signal transduction via Janus kinase 2[J]. Biol Chem,2001,276(35):32635~32641. 5 Barclay J L, Kerr L M, Arthur L, et al. In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2[J]. Mol Endocrinol, 2010,24(1):204~217. 6 Bernabeu I, Alvarez-Escolá C, Quinteiro C, et al. The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly[J]. Clin Endocrinol Metab, 2010,95(1):222~229. 7 de Vos A M, Ultsch M, Kossiakoff A A. Human growth hormone and extracellular domain of its receptor:Crystal structure of the complex[J]. Science, 1992, 255(5042):306~312. 8 Deng L, He K, Wang X, et al. Determinants of growth hormone receptor down regulation[J]. Mol Endocrinol, 2007, 21(7):1537~1551. 9 Flores-Morales A, Greenhalgh C J, Norstedt G, et al. Negative regulation of growth hormone receptor signalling[J]. Mol Endocrinol, 2006, 20(2):241~253. 10 Frank S J, Fuchs S Y. Modulation of growth hormone receptor abundance and function:Roles for the ubiquitin proteasome system[J]. Biochim Biophys Acta, 2008, 1782:785~794. 11 Gent J, Van Kerhof P, Roza M, et al. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis[J]. Proc Natl Acad Sci USA, 2002, 99:9858~9863. 12 Hansen J A, Lindberg K, Hilton D J, et al. Mechanism of inhibition of growth hormone receptor signalling by suppressor of cytokine signalling proteins[J]. Mol Endocrinol, 1999, 13:1832~1843. 13 Higham C E, Trainer P J. Growth hormone excess and the development of growth hormone receptor antagonists[J]. Exp Physiol, 2010, 93(11):1157~1169. 14 Leung D W, Spencer S A, Cachianes G, et al. Growth hormone receptor and serum binding protein:Purification, cloning and expression[J]. Nature, 1987, 330(6148):537~543. 15 Litterst C M,Kliem S, Lodrini M,et al. Coactivators in gene regulation by STAT5[J]. Vitam Horm,2005,70:359~386. 16 Ram P A, Waxman D J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms[J]. Biol Chem, 1999, 274:35553~35561. 17 Rosenfeld R G, Kofoed E, Buckway C, et al. Identification of the first patient with a conformed mutation of the JAK-STAT system[J]. Pediatr Nephrol, 2005, 20(3):303~305. 18 Rowlinson S W, Yoshizato H, Barclay J L, et al. An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway[J]. Nat Cell Biol, 2008, 10(6):740~747. 19 Starr R, Metcalf D, Elefanty A G, et al. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1[J]. Proc Natl Acad Sci USA, 1998, 95(24):14395~14399. 20 Tsushima T, Friesen H G. Radio receptor assay for human growth hormone[J]. J Clin Endocrinol Metab, 1973, 37(2):334~337. 21 Waters M J, Books A J. Growth hormonal receptor:Structure function relationships[J]. Horm Res Pediatr,2011, 76(Suppl 1):12~16. 22 Wei Y, Rhani Z, Goodyer C G. Characterization of growth hormone receptor messenger ribonucleic acid variants in human adipocytes[J]. Clin Endocrinol Metab, 2006, 91(5):1901~1908. 23 Yang N, Langenheim J F, Wang X, et al. Activation of growth hormone receptors by growth hormone and growth hormone ant agonist dimers:Insights into receptor triggering[J].Mol Endocrinal, 2008, 22(4):978~988. |