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Effect of Exogenous Hydrogen Sulfide on Skeletal Muscular Fatigue

SUN Hong-zhao1,ZHAO Shu-zhen2,LU Kai1,HOU Feng-tian1,HAN Jia-xiu1,ZHAO Peng-fei1,ZHANG Xing-mei1,ZHANG Li1,ZHANG Xue1,HAN Zeng-xiao1,LIU Qing-qing1,LIU Xue-lian1   

  1. (1. Biological Department, Qi Lu Normal University, Jinan 250013, China;2. High-Tech Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China)
  • Online:2014-01-20 Published:2014-02-27

Abstract: To investigate the effects of NaHS, an exogenous hydrogen sulfide donor, on skeletal muscular fatigue. Toad gastrocnemius was stimulated by pulse electric curent. The results showed that NaHS at concentrations of 5×10-4 mol/L (in vitro, P < 0.01), 1×10-3 mol/L (in vitro, P < 0.01), 2×10-3 mol/L (in vitro, P < 0.01) and 5.6 mg/(kg·BW) (in vivo, P < 0.01) could prolong the time of contraction amplitude decreasing to 90%, 50% and 10% of the maximum contraction amplitude. The study showed that exogenous hydrogen sulfide had effect on antifatigue.

Key words: sodium hydrosulfide; toad gastrocnemius; muscular fatigue