›› 2013, Vol. 40 ›› Issue (11): 204-208.

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Research Progress on the QseBC Two-component Regulatory System

YUAN Xue-zhen1, DU Xiang-dang1, QIN Shang-shang2, LI Xin-sheng1   

  1. 1. Engineering College of Animal Husbandry and Veterinary Science, Henan Agricultural University, Zhengzhou 450002, China;
    2. Zhengzhou University School of Pharmaceutical Sciences, Zhengzhou 450001, China
  • Revised:2013-08-07 Online:2013-11-20 Published:2013-12-19

Abstract: The QseBC two-component regulatory system is widespread in the gram-negative bacillus, which plays an important role in the regulation of bacterial virulence. In this article, the composition of the QseBC two-component regulatory system and its role in bacterial pathogenicity, especially in E.coli, S.typhimurium, Actinobacillus, E.tarda and A.hydrophila were summarized. The further study on QseBC may aid to drug design based on the bacterial virulence as the new targets, and provide new ideas for resolving the problem of antimicrobial resistance.

Key words: QseBC; two-component regulatory system; pathogenicity