p53和TGF-β在细胞生长调控中的相互作用及其与疾病的研究进展

›› 2012, Vol. 39 ›› Issue (4): 73-75.

• 生物技术 • Previous Articles Next Articles

Research on Interaction and Diseases between p53 and TGF-β in Regulation of Cell Growth

ZHENG Yan-sheng, ZHENG Shi-min, GAO Xue-li

College of Animal Medicine, Northeast Agricultural University, Harbin 150030,China

Received:2011-08-21 Revised:1900-01-01 Online:2012-04-20 Published:2012-04-20

Abstract

Abstract: p53 is the first discovered member of tumor suppression protein family, which can sense many cell signals to regulate cell proliferation, apoptosis and differentiation. TGF-β is a important physiological and biochemical regulator in organism which plays a important role in cell growth, differentiation, embryonic development, damage repair and so on. p53 has a close relationship with TGF-β signaling pathway. The relationship of p53 and TGF-β in cell growth regulation in latest years were reviewed.

Key words: p53; TGF-β; cell growth regulation

CLC Number:

Q813

ZHENG Yan-sheng;ZHENG Shi-min;GAO Xue-li. Research on Interaction and Diseases between p53 and TGF-β in Regulation of Cell Growth[J]. , 2012, 39(4): 73-75.

[1]	LI Peiqi, KANG Jie, WANG Keyao, WANG Huimin, HAN Yufeng, WANG Tinghui, CUI Liang, ZHANG Jian, DENG Ruiqiang, DUAN Zhibian. Effect of Compound Traditional Chinese Medicine Water Extract on TGF-β1/Smad Pathway in Liver of Ascites Syndrom in Broilers [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1860-1869.
[2]	SUN Yishan, YANG Fei, HUANG Tao. Effects of Interference and Overexpression of BAMBI Gene on the Phenotype and Function of Porcine Ovarian Granulosa Cells [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(2): 563-573.
[3]	LIN Changjie, LI Ting, TANG Xin, CHEN Yingyu, GUO Aizhen, HU Changmin. Advances in the Mechanism of Epithelial-mesenchymal Transition for Breast Cancer Promotion and Drug Intervention [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 117-123.
[4]	DING Yangyang, ZHAO Huijing, GUAN Weijun, HE Xiaohong, PU Yabin, JIANG Lin, MA Yuehui, ZHAO Qianjun. Isolation and Identification of Goat Dermal Papilla Cells and Expression of TGF/β-smad Pathway Related Genes [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(9): 2724-2731.
[5]	TIAN Jie，REN Pei-you，LI Rui，LIU Chun-yu. Study on Pseudolaric Acid B Inhibited Cell Growth through P53, Caspase 8 and Caspase 9 in MCF-7 Cells [J]. , 2014, 41(5): 155-158.
[6]	LIU Xing-liang;;LI Jin-quan;;ZHANG Wen-guang;;WANG Zhi-xin;;ZHANG Yong-bin;ZHANG Yan-jun;;CHANG Zi-li;;LI Chun;;WU Ping;;LIU Wei;;GAO Ai-qin;. The Expression of Cashmere Goat TGF-βRⅡin Skin [J]. , 2010, 37(7): 86-85.
[7]	WEI Han;GENG Guo-xia;LI Qing-wang;LI Jian;TIAN Yong-zhi. Study on Anti-cervical Cancer Activity of Euphorbia Humifusa [J]. , 2010, 37(3): 192-193.
[8]	NA Risu;LIU Changqing;LU Taofeng;DAO Erji;GUAN Weijun;MA Yuehui;. The Post-translational Modification of Tumor-inhibiting Factor P53 [J]. , 2008, 1(9): 68-71.
[9]	LI Zhen-zu;DONG Chuan-he;LI Hong-bin;DU Li-xin . The Signaling of TGF-β Superfamily and the Effect on Ovarian Development [J]. , 2008, 1(3): 43-46.
[10]	NIE Hao;;DU Weihua;HAO Haisheng;WANG Zongli;WANG Dong;ZHU Huabin. Roles of CDK2 and P53 in Centrosome Duplication Regulation [J]. , 2008, 1(12): 105-109.

Research on Interaction and Diseases between p53 and TGF-β in Regulation of Cell Growth

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments