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›› 2012, Vol. 39 ›› Issue (4): 17-20.

• 生物技术 • Previous Articles Next Articles

Effect of TCDCA on Lipocortin-1 Expression in Fibroblast-like Synoviocytes in Rats with Adjuvant Arthritis

GUAN Hong^1,2, MAO Wei^1,2, LI Pei-feng^1,2, LIU Ming-qiang^1,2

1. College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018,China;2. Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease,Ministry of Agriculture,Hohhot 010018,China

Received:2011-12-16 Revised:1900-01-01 Online:2012-04-20 Published:2012-04-20

Abstract

Abstract: To observe the effect of taurochenodeoxycholic acid(TCDCA) on lipocortin 1(LC-1) expression in fibroblast-like synoviocytes (FLS) cell in rats with adjuvant arthritis, and to explore its effect mechanism. Adjuvant arthritis was induced by Freund's complete adjuvant in rats. The synovial cells from AA rats were cultured with synovial tissue. The effect of TCDCA on the expression of LC-1 mRNA was examined quantitatively by fluorescent quantitative RT-PCR. TCDCA decreased significantly the expression of LC-1 mRNA in AA FLS cell (P<0.05), compared with that in model group. TCDCA can significantly promote the expression of LC-1 mRNA in AA FLS cell.

Key words: taurochenodeoxycholic acid; lipocortin-1; fluorescent quantitative RT-PCR; fibroblast-like synoviocytes

CLC Number:

S859.1

GUAN Hong;MAO Wei;LI Pei-feng;LIU Ming-qiang;. Effect of TCDCA on Lipocortin-1 Expression in Fibroblast-like Synoviocytes in Rats with Adjuvant Arthritis[J]. , 2012, 39(4): 17-20.

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Effect of TCDCA on Lipocortin-1 Expression in Fibroblast-like Synoviocytes in Rats with Adjuvant Arthritis

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