Abstract: To investigate the contamination,drug resistance and virulence of the pig-borne Salmonella in slaughter pigs,131 samples were collected directly from the intestine of slaughter pigs in a pig slaughterhouse in Nanning of Guangxi,randomly. And 45 Salmonella strains (34.35% positive),of which 14 strains of Salmonella typhimurium, 2 strains of Salmonella paratyphi and 3 strains of Salmonella enteritidis were isolated and characterized by differential medium and biochemical identification.The drug resistance of isolated strains was tested against antibacterial drugs by Kirby-Barer method, and all strains displayed drug resistance,but 44 strains (97.78%) were found to be the strain with multi-drug resistance. Among the 45 resistant strains of Salmonella isolates,40 strains (88.89%) were found to be pathogenic for mice. The results indicated that the Salmonella contamination in slaughter of pigs was evident in Nanning and drug resistant rate was very serious and had strong pathogenicity. In order to reduce the drug resistance pathogens and ensure pork and pork products food safety, it is necessary to take effective measures to control Salmonella contamination in pigs and reduce the use of antibiotics in animal feedstuffs.

Key words: Nanning; intestine of slaughter pigs; Salmonella; isolation and identification; drug resistance; pathogenicity