Abstract: To provide the basis of APS used for swine fever vaccine diluent and vaccine adjuvant. The rabbits in three groups were intramuscular injected with activated thermostabilized vaccine of swine fever with diluent of 1% astragalus polysaccharide (astragalus polysaccharide,APS) injection, dedicated diluent for swine fever vaccine and physiological saline respectively. After vaccination, the activty of lymphocyte, antibody of swine fever in serum and contents of interleukin 2, interleukin 6, interferon γ and neopterin were determined to evaluate the impact of these three diluents on vaccination effects to swine fever vaccine.The results showed that APS raised contents of antibody of swine fever in serum and some cell factors. APS could be used for swine fever vaccine diluent or improved diluent and swine fever vaccine adjuvant.

Key words: astragalus polysaccharide; activity of lymphocytes; antibody; interleukin; interferon; Neopterin