Abstract: For understanding epidemics dynamic,vaccine immune status and disease control effect of the scale goats farm,the breeding goat farm and free-range raising farm. We do major epidemiologically investigate and etiologically detect for epidemic disease in the Zunyi,Liupanshui,Bijie southeast of the Guizhou province from 2007 to 2010. Providing a evidence for the next step of flocks epidemics counter-measures decision-making.The result showed that the average antibody positive rate of FMD typeⅠ,FMD type O,inapparent infection of FMD,Brucella,and GPV was 58.85%, 47.83%, 10.39%, 7.67%, 90.00% in the nine districts;contemporary we detected the GPV,lamb colibacillosis,Staphylococcus aureus disease and mange mite disease etc,above data showed that although strengthen the immune antibody titer prevention and control,but is still low,and mixed infection bacterial disease common see,that become the a link cannot be neglected in goats epidemic prevention.

Key words: Guizhou province; sheep disease; serology; nosetiology