Abstract: Prion protein（PrPC）has received great attention as the major associated pathogenic agent, although a great deal has been known about the role of PrPC in the process of disease, the normal function of PrPC still remain elusive. In the present study, a variety of functions have been proposed for mammalian PrPC. Such as nucleocytoplasmic isoforms of PrPC, interactions with ligand and Cu2+, and can be acquired by plasm membrane using endocytosis and internalization. PrPC has multiple physiological functions, including protection of nerve system,assitance of cell death, differentiation and adhesion, and transduction of cell signaling. Thus, overview of the physiological function of PrPC will contribute to the cure of prion disease and further research of prion protein.

Key words: prion protein; PrPC; physiologic function