Abstract: The bactericidal/permeability-increasing protein (BPI) is an antibiotic-and endotoxin-neutralizing protein in granulocytes and epithelial cells. It is a positive protein which molecular weight range between 50 and 60 ku. BPI is mainly found in azurophili granules and surface of PMN (PN4NL) from people, cattle, rabbits and other mammals. BPI can combine with the LPS and endotoxin of gram negative bacteria and produce effects of anti-endotoxin and kill bacterial. Therefore, it has a good future of application at prevention and cure of disease of Gram-negative bacterial. BPI initial found in the human protein because of its bactericidal effect and strong anti-endotoxin role. In recent research, it has been also found that it has many other functions, such as the effects of anti-fungal and killing parasites. Therefore it has been known as “super antibiotics” of the future.

Key words: bactericidal/permeability-increasing protein; endotoxin; neutrophil