Abstract: As one of a few sperm membrane surface protein involved in sperm-egg binding and fusion, fertilin β is an important material that many mammal sperms all have. It is a sort of fusion protein in the ADAMs families. It has complete structural domain of the ADAMs family; meanwhile, because of its feature in disintegrin construction, it plays an important role in sperm-egg plasmalemma binding and fusion, and it is considered as an important vaccine-barn antigen.

Key words: fertilin β; disintegrin domain; sperm-egg binding and fusion