Abstract: To develop a diabetic mouse model to determine the data of biological property in MKR mice, a model in which expression of a dominant-negative IGF-I receptor in the skeletal muscle leads to systemic insulin resistance and diabetes, so as to provide a platform for researches about the type 2 diabetes.MKR mice were received from the National Institutes of Health, USA, and propagated naturally. These mice were followed up for body weight，blood glucose level，faculty of memory，fatigue-resistant，oxygen-deficiency-enduring and experiment of anaesthesia tolerance, using wild-type Kunming mice or C57BL/6J mice as controls. Results showed that these mice were hyperglycemia from 3 weeks of age onward and the body weight increase slowed down with increasing of ages, which is very significant than the controlling littermates(P<0.01). MKR mice in the other were worse than Kunming littermates, that is also significant(P<0.01). Therefore, MKR mice model should be estabolished as a good king of animal model in the type 2 diabetes.

Key words: type 2 diabetes; MKR mice; biology