Abstract: We report the effects of candidate gene Dopamine Receptor D1 (DRD1) gene on selfbiting in the current study. In this study, partial sequence of Dopamine Receptor D1 genes were firstly extracted from feet in American mink, and were amplified using Polymerase Chain Reaction (PCR) method, then sequenced. Now the sequence has been sent to Gene Bank with registration, and the Accession Number is EU249297. Comparison the fragment sequence of different individuals, we found T→C mutation, but coded amino acid had no change. Then followed by single strand conformation polymorphism (PCR-SSCP) analysis, there showed three kinds of genotypes: AA, AB, BB. The correlation between the genotypes with the in selfbiting behavior was analyzed, the results showed that the frequency of allele A is higher than allele B, the AA genotypes in control group were higher than that of selfbiting group, and is different significantly (P<0.05).

Key words: American mink; dopamine receptor D1 gene; selfbiting behavior; PCR-SSCP 