Abstract: The tumor-inhibiting factor P53 is most closely related with cancer， and it must be post-translational modified before performing its regular function. The comprehensive realization of the process has great significance in molecular mechanism of tumorigenesis and treatment and prevention of tumour. This article generality discussed several questions about the posttranslational modification of P53 including phosphory-lation modification， acetylation modification， smallubiquitin-like modification and the ubiquitinproteasome pathway of P53， and illuminated its regulatory networks. This discussion supplied the theory basis to have a better realization in the molecular mechanism of treatment and prevention of tumour.

Key words: P53; post-translational modification; tumour