熊果酸介导HIF-1α缓解木质化鸡胸肉发生的潜在作用机制研究

doi:10.16431/j.cnki.1671-7236.2024.04.016

Abstract

Abstract: The lesion rate of woody breast is as high as 20% in fast-growing White feather broiler,it seriously reduces consumers’ desire to buy,and is not conducive to post-processing,resulting in relatively high economic losses.Hypoxia is an important cause of woody breast,and hypoxia inducible factor 1α (HIF-1α) is a key factor in regulating cell function under hypoxia.Ursolic acid has the effects of anti-oxidation,anti-inflammatory and regulating glucose metabolism,and can regulate the expression of HIF-1α through adenylate-activated protein kinase (AMPK) and phosphatidylinositol kinase-3 kinase-protein kinase B (PI3K/Akt) signaling pathways.Therefore,the author reviews the pathogenesis of woody breast caused by hypoxia and how HIF-1α mediated glucose metabolism,oxidative stress and inflammatory responses are regulated by ursolic acid,and further analyzes the potential mechanism of ursolic acid regulating HIF-1α to alleviate the occurrence of woody breast through AMPK,PI3K/Akt and other signaling pathways.

Key words: woody breast; ursolic acid; hypoxia inducible factor 1α (HIF-1α)

CLC Number:

S831.7

ZHANG Xiwen, LI Xiang, YIN Yue, ZHAO Yurong. Study on Ursolic Acid Mediated Hypoxia Inducible Factor 1α Potential Mechanisms for Alleviating the Occurrence of Woody Breast[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(4): 1480-1489.

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Study on Ursolic Acid Mediated Hypoxia Inducible Factor 1α Potential Mechanisms for Alleviating the Occurrence of Woody Breast

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