Abstract: Pathogenic Escherichia coli (E.coli) as a member of Enterobacteriaceae and one of the zoonotic pathogens,can cause human and animal infections through a variety of ways and cause different E.coli disease types under certain conditions.Due to the large number of serotypes and virulence factors,the severe trend of drug resistance,the existence of biofilm and other factors,the epidemic trend of colibacillosis is complex and the development of vaccines is difficult of pathogenic E.coli,which brings certain economic losses to the domestic and foreign livestock and poultry breeding industry.High-pathogenicity island (HPI) was first discovered in Yersinia,which was proved to be a genomic island necessary for its virulence phenotype.Due to the horizontal transfer mechanism of bacteria,the virulence island is widely detected in other Enterobacteriaceae.Among them,the HPI pathogenicity island was also detected in pathogenic E.coli such as enterohemorrhage E.coli (EHEC) and shiga toxin-producing E.coli (STEC),which was confirmed to affect the virulence of pathogenic E.coli,participate in the iron uptake of pathogenic E.coli and mediate the host immune response.In order to further understand the iron regulation mechanism,pathogenic characteristics,mediated cellular immune response and horizontal transfer pathway of HPI virulence island in pathogenic E.coli,this paper summarizes the structure of HPI virulence island,how to regulate Yersinia siderophore,the pathogenicity of HPI virulence island and its regulation of cellular immune response,and the horizontal transfer of HPI virulence island.It is expected to provide help for the pathogenic mechanism of E.coli and the prevention and control of E.coli disease.

Key words: zoonotic pathogen; pathogenic Escherichia coli; HPI virulence island; horizontal transfer