半乳糖凝集素1的生物学功能及其在鹿茸再生过程中的作用研究进展

doi:10.16431/j.cnki.1671-7236.2022.10.006

Abstract

Abstract: Galectin-1 (GAL-1) is a β-galactoside-binding protein with a molecular mass of about 14 ku,which is distributed in many different types of cells and tissues,and has a wide range of intracellular and extracellular biological activity,involved in the regulation of various physiological and pathological processes.GAL-1 regulates cell proliferation in a dose-dependent and cell-specific bidirectional manner,promotes angiogenesis through the vascular endothelial growth factor receptor 2 (VEGFR2) pathway,participates in the immune regulation of the body,induces T cell apoptosis,inhibits T cell proliferation and antigen-presenting cell activation.In addition,GAL-1 is considered as a marker of various types of tumors,and tumor cells secrete GAL-1 to promote angiogenesis and autoimmune escape in tumors.Deer antler is the unossified and young horns with densely hairy derived from the head of the deer,and it is also the only bone appendage that can achieve periodic holomorphosis in mammals.The regeneration of deer antler is based on the process of deer antler stem cells proliferation. GAL-1 is overexpressed in deer antler stem cells,and the regeneration process of deer antler is closely related to the biological function of GAL-1.However,the role of GAL-1 in deer antler regeneration remains to be further investigated.The authors reviewed the protein structure and biological functions of GAL-1,as well as its role in the regeneration of deer antler,and hopes to bring new enlightenment to the study of the function of GAL-1 and the mechanism of deer antler regeneration.

Key words: galectin-1; deer antler; cell proliferation; angiogenesis; immunosuppression

CLC Number:

S825

LI Xunsheng, SHI Wanwan, XING Baorui, ZHOU Jue, LI Chunyi, SUN Hongmei. Research Progress on the Biological Function of Galectin-1 and Its Role in Deer Antler Regeneration[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(10): 3746-3755.

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Research Progress on the Biological Function of Galectin-1 and Its Role in Deer Antler Regeneration

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