Abstract: In recent years,it has resulted in significant misuse and overuse of antibiotics contributing to the emergence of antibiotic resistant,drug residue and food safty.Especially,the emergence of multi-resistant and pan resistant bacteria has threated the human health.Therefore,it is necessary to find a safe and effective antibiotic substitute to ensure animal-derived food,improve animal health and promote social development.Bacteriophage are defined as viruses that infect bacteria,fungus and actinomycetes.Compared with traditional antibiotics,bacteriophage has many advantages for therapeutic purpose,including existence wildly,high specificity,safety,low cost,and become the weapon with human fighting bacterial infections.The early history of phage therapy has been controlled by bacterial infection.However,the emergence of antibiotic and chemical antibacterial agent,phage research and therapy was largted to medical history in the western countries.Until 1980s,the emergence of multidrug resisitant bacteria has led researcher to re-consider phage therapy.With the development of modern biotechnology,new investigations were focused on the use of phage therapy in the treatment of human infections as well as in crop,veterinary and food safety.The authors reviewed the biological characteristics of phage,advantages and disadvantages of phage therapy,prevention E.coil,Salmonella and Campylobacter infections in livestock and poultry,and provided a theoretical reference for the further applications in animal production.

Key words: bacteriophage; bacterial infection; multi-drug resistant