雌激素及其受体调控卵母细胞成熟的研究进展

doi:10.16431/j.cnki.1671-7236.2018.07.024

Abstract

Abstract:

Nowadays many women suffer from many reproductive-related diseases such as infertility,spontaneous abortion and birth defects.The main internal factors are the germ cell abnormal meiosis and the decline of oocyte quality.It is well known that estrogen not only regulates the estrus and sexual behavior of mammals, but also involves in the regulation of the growth and development of oocytes.Estrogen receptor, as a kind of steroid receptors, plays a vital role in mediating the genomics and non-genome effects of estrogen.At present,the reports about estrogen receptors regulating oocyte maturation are mostly focused on the teleosts, especially the novel membrane receptor GPR30, but few reports on mammalian.So the structure and distribution of estrogen nuclear receptor ER α,ER β and new membrane receptor GPR30 are described in this review.Moreover,the research progress of different types of ligands for membrane receptor GPR30 and the interaction between estrogen receptors and oocyte development are introduced.The analysis have showed that estrogen's nuclear receptors and membrane receptor may play a different regulatory role in the process of oocyte maturation.Besides, this article further reveals the potential mechanism of estrogen and its receptors in the regulation of maturation of oocyte.

Key words: estrogen; estrogen receptors; oocyte; mature regulation

CLC Number:

S852.2

GE Junbang, ZHAO Hui, MA Baohua. Research Progress on Regulation of Oocyte Maturation by Estrogen and Its Receptors[J]. , 2018, 45(7): 1919-1925.

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Research Progress on Regulation of Oocyte Maturation by Estrogen and Its Receptors

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