[1] Baulcombe D. RNA silencing in plants[J]. Nature, 2004, 431(7006):356-363.
[2] Jonesrhoades M W, Bartel D P, Bartel B. microRNAs and their regulatory roles in plants[J].Plant Biology, 2006, 57(57):19-53.
[3] Vaucheret H. Post-transcriptional small RNA pathways in plants:Mechanisms and regulations[J]. Genes & Development, 2006, 20(7):759-771.
[4] Axtell M J. Classification and comparison of small RNAs from plants[J]. Plant Biology, 2013, 64(64):137-159.
[5] Jyothi M N, Rai D V, Babu R N. Identification and characterization of high temperature stress responsive novel miRNAs in french bean (Phaseolus vulgaris)[J]. Applied Biochemistry and Biotechnology, 2015, 176(3):835-849.
[6] Voinnet O. Origin, biogenesis, and activity of plant microRNAs[J]. Cell, 2009, 136(4):669-687.
[7] Aryal R, Yang X, Yu Q, et al. Asymmetric purine-pyrimidine distribution in cellular small RNA population of papaya[J]. BMC Genomics, 2012, 13(1):1-14.
[8] Lee S R, Collins K. Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs[J]. Nature Structural & Molecular Biology, 2007, 14(7):604-610.
[9] Whitehead K A, Langer R, Anderson D G. Knocking down barriers:Advances in siRNA delivery[J]. Nature Reviews Drug Discovery, 2010, 8(2):129-138.
[10] Rajagopalan R, Vaucheret H, Trejo J, et al. A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana[J]. Genes & Development, 2007, 20(20):3407-3425.
[11] Brodersen P, Sakvarelidze-Achard L, Bruun-Rasmussen M, et al. Widespread translational inhibition by plant miRNAs and siRNAs[J].Science, 2008, 320(5880):1185-1190.
[12] Baumberger N, Baulcombe D C. Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs[J].Proc Natl Acad Sci USA, 2005, 102(33):11928-11933.
[13] Khvorova A, Reynolds A, Leake D, et al. Methods and compositions for selecting siRNA of improved functionality:WO, US9228186[P]. 2016.
[14] Xie Z, Johansen L K, Gustafson A M, et al. Genetic and functional diversification of small RNA pathways in plants[J]. PLoS Biology, 2004, 2(2):642-652.
[15] Borsani O, Zhu J, Verslues P E, et al. Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis[J]. Cell, 2005, 123(7):1279-1291.
[16] Chan S W, Zilberman D, Xie Z, et al. RNA silencing genes control de novo DNA methylation[J]. Science, 2004,303(5662):1336.
[17] Kasschau K D, Fahlgren N, Chapman E J, et al. Genome-wide profiling and analysis of Arabidopsis siRNAs[J].PLoS Biology, 2007, 5(3):e57.
[18] Xie Z, Allen E, Wilken A, et al. DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana[J]. Proc Natl Acad Sci USA, 2005, 102(36):12984-12889.
[19] Havecker E R, Wallbridge L M, Hardcastle T J, et al. The Arabidopsis RNA-directed DNA methylation argonautes functionally diverge based on their expression and interaction with target loci[J]. Plant Cell, 2010, 22(2):321-334.
[20] Qi Y, He X, Wang X J, et al. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation[J]. Nature, 2006, 443(7114):1008-1012.
[21] Zilberman D, Cao X, Jacobsen S E. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation[J].Science, 2003, 299(5607):716-719.
[22] Macrae I J, Zhou K, Li F, et al. Structural basis for double-stranded RNA processing by Dicer[J]. Science, 2006, 311(5758):195-198.
[23] Vermeulen A, Behlen L, Reynolds A, et al. The contributions of dsRNA structure to Dicer specificity and efficiency[J]. RNA, 2005, 11(5):674-682.
[24] Fernandes J C, Qiu X, Winnik F M, et al. Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro:Optimization studies[J]. International Journal of Nanomedicine, 2011, 7(1):5833-5845.
[25] Pei Y, Hancock P J, Zhang H, et al. Quantitative evaluation of siRNA delivery in vivo[J]. RNA, 2010, 16(12):2553-2563.
[26] Wen Y,Meng W S. Recent in vivoevidences of particle-based delivery of small-interfering RNA (siRNA) into solid tumors[J]. Journal of Pharmaceutical Innovation, 2014, 9(2):158-173.
[27] Singh N, Agrawal A, Leung A K L, et al. Effect of nanoparticle conjugation on gene silencing by RNA interference[J]. Journal of the American Chemical Society, 2010, 132(24):8241-8253.
[28] Watts J K, Deleavey G F, Damha M J. Chemically modified siRNA:Tools and applications[J]. Drug Discovery Today, 2008, 13(19-20):842-855.
[29] Hong C A, Nam Y S. Functional nanostructures for effective delivery of small interfering RNA therapeutics[J]. Theranostics, 2014, 4(12):1211-1232.
[30] Al-Abd A M, Lee S H, Kim S H, et al. Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in vitro[J].J Control Release, 2009, 137(2):130-135.
[31] Kim S H, Jeong J H, Lee S H, et al. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy[J]. J Control Release, 2006, 116(2):123-129.
[32] Kim S H, Jeong J H, Lee S H, et al. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer[J].J Control Release, 2008, 129(2):107-116.
[33] Choi S W, Lee S H, Mo k H, et al. Multifunctional siRNA delivery system:Polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide[J]. Biotechnology Progress, 2010, 26(1):57-63.
[34] Jung S, Lee S H, Mok H, et al. Gene silencing efficiency of siRNA-PEG conjugates:Effect of PEGylation site and PEG molecular weight[J]. J Control Release, 2010, 144(3):306-313.
[35] Oishi M, Nagasaki Y, Itaka K, et al. Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells[J]. Journal of the American Chemical Society, 2005, 127(6):1624-1635.
[36] Dohmen C, Fröhlich T, Lächelt U, et al. Defined folate-PEG-siRNA conjugates for receptor-specific gene silencing[J]. Molecular Therapy Nucleic Acids, 2012, 1(1):e7.
[37] Nothisen M, Kotera M, Voirin E, et al. Cationic siRNAs provide carrier-free gene silencing in animal cells[J]. Journal of the American Chemical Society, 2009, 131(131):17730-17731.
[38] Perche P, Nothisen M, Bagilet J, et al. Cell-penetrating cationic siRNA and lipophilic derivatives efficient at nanomolar concentrations in the presence of serum and albumin[J].J Control Release, 2013, 170(1):92-98.
[39] Rozema D B, Lewis D L, Wakefield D H, et al. Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes[J]. Proc Natl Acad Sci USA, 2007, 104(32):12982-12987.
[40] Meyer M, Dohmen C, Philipp A, et al. Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate[J].Molecular Pharmaceutics, 2009, 6(3):752-762.
[41] Lee J Y, Lee S H, Oh M H, et al. Prolonged gene silencing by siRNA/chitosan-g-deoxycholic acid polyplexes loaded within biodegradable polymer nanoparticles[J]. J Control Release, 2012, 162(2):407-413.
[42] Lee S H, Mok H, Lee Y, et al. Self-assembled siRNA-PLGA conjugate micelles for gene silencing[J]. J Control Release, 2011, 152(1):152-158.
[43] Park K, Yang J A, Lee M Y, et al. Reducible hyaluronic acid-siRNA conjugate for target specific gene silencing[J]. Bioconjugate Chemistry, 2013, 24(7):1201-1209.
[44] Kim J S, Mi H O, Park J Y, et al. Protein-resistant, reductively dissociable polyplexes for in vivo, systemic delivery and tumor-targeting of siRNA[J].Biomaterials, 2013, 34(9):2370-2379.
[45] Namgung R, Kim W J. A highly entangled polymeric nanoconstruct assembled by siRNA and its reduction-triggered siRNA release for gene silencing[J]. Small, 2012, 8(20):3209-3219.
[46] Hong C A, Kim J S, Lee S H, et al. Reductively dissociable siRNA-polymer hybrid nanogels for efficient targeted gene silencing[J]. Advanced Functional Materials, 2013, 23(3):316-322.
[47] Zimmermann T S, Lee A C, Akinc A, et al. RNAi-mediated gene silencing in non-human primates[J].Nature, 2006, 441(7089):111-114.
[48] Akinc A, Goldberg M, Qin J, et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver[J]. Mol Ther, 2009, 17(5):872-879.
[49] Sperling R A, Rivera G P, Zhang F, et al. Biological applications of gold nanoparticles[J]. Chemical Society Reviews, 2008, 37(9):1896-1908.
[50] Novina C D, Sharp P A. The RNAi revolution[J]. Nature, 2004, 430(6996):161-164.
[51] Yin H, Kanasty R L, Eltoukhy A A, et al. Non-viral vectors for gene-based therapy[J].Nature Reviews Genetics, 2014, 15(8):541-555.
[52] Liu S, Asparuhova M, Brondani V, et al. Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A[J]. Nucleic Acids Research, 2004, 32(12):3752-3759.
[53] Lee S H, Yun S, Lee J, et al. RasGRP1 is required for human NK cell function[J]. Journal of Immunology, 2009, 183(183):7931-7938.
[54] Lee S H, Yun S, Piao Z H, et al. Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2[J]. Journal of Immunology, 2010, 185(2):917-928.
[55] Bedel R, Thiery-vuillemin A, Grandclement C, et al. Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells[J]. Cancer Research, 2011, 71(5):1615-1626.
[56] Lozano E, Dominguez-villar M, Kuchroo V, et al. The TIGIT/CD226 axis regulates human T cell function[J]. Journal of Immunology, 2012, 188(8):3869-3875.
[57] Fenizia C, Fiocchi M, Jones K, et al. Human T-cell leukemia/lymphoma virus type 1 p30, but not p12/p8, counteracts Toll-like receptor 3(TLR3) and TLR4 signaling in human monocytes and dendritic cells[J]. Journal of Virology, 2014, 88(1):393-402. |