动物细胞流加培养工艺研究进展

doi:10.16431/j.cnki.1671-7236.2016.01.026

Abstract

Abstract: Nowadays, fed-batch culture becomes the predominant mode of the large-scale animal cell culture process.It is widely used in the production of biological products, and promotes the development of the modem biological industry.In the process of culture, the cells should be provided with nutrient for its metabolism and products synthesis.The by-produces of the cells should also be controlled to relief the contradiction between nutrient consumption and by-produces accumulation.The advantage of fed-batch culture is drawn forth from analyzing the characteristics.In this paper, we reviewed the cell metabolism coupled with gene regulation, the optimization of culture process and control strategies linked with on-line monitor in the fed-batch culture process.On the basis of above-mentioned survey, the existent problems and prospects for animal cell cultivation were discussed.

Key words: fed-batch animal cell culture technology; cellular metabolism; medium; control strategy

CLC Number:

Q813.1⁺1

LUO Hai-yan, DOU Bing-ran, JIANG Kai-wei, HONG Hou-sheng. Research Progress on Technology of Fed-batch in Animal Cell Culture[J]. , 2016, 43(1): 176-181.

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Research Progress on Technology of Fed-batch in Animal Cell Culture

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