赤芍水提物与抗菌药联合对耐药大肠杆菌抑菌作用的研究

doi:10.16431/j.cnki.1671-7236.2015.11.037

Abstract

Abstract: The assay was aimed to explore the combination of aqueous extract of Radix Paeoniae Rubra and antibiotics against drug-resistant E.coli, we used the broth micro-dilution method and micro-dilution checkerboard technique to determine the minimum inhibiotory concentration (MIC) and fractional inhibitory concentration index (FICI).The results showed that the FICI of aqueous extract of Radix Paeoniae Rubra combined with ceftriaxone sodium, amoxicillin, ciprofloxacin, norfloxacin, levofloxacin, fosfomycin, mequindox, clinafloxacin, sulfamonomethoxine, gatifloxacin, amikacin, ceftazidime, lincomycin, ceftiofur sodium, florfenicol, azithromycin, cefotaxime and rifampicin were 0.27, 2.50, 1.02, 1.01, 3.00, 0.28, 1.02, 1.02, 1.02, 2.02, 1.02, 0.75, 0.56, 0.75, 0.50, 3.00, 0.75 and 0.38, respectively.The results indicated that the aqueous extract of Radix Raeoniae Rubra combined with ceftriaxone sodium, fosfomycin, florfenicol and rifampin had synergy effects;Combined with lincomycin, ceftiofur sodium, cefotaxime and ceftazidime had additive effect;Combined with amoxicillin, levofloxacin, gatifloxacin and azithromycin had antagonism effect;Combined with ciprofloxacin, norfloxacin, mequindox, clinafloxacin, sulfamonomethoxine and amikacin showed independent action.

Key words: Radix Paeoniae Rubra; aqueous extract; drug-resistant E.coli; fractional inhibitory concentrations (FIC)

CLC Number:

S852.61⁺4

PAN Jie, LIU Zeng-yuan, LIANG Zheng, WU Yong-ji, SONG Jian-wu, SUN Yan-jie, XU Su-ping, HUANG Kai, SI Hong-bin. Study on the Anti-bacterial Effects of Aqueous Extract of Radix Paeoniae Rubra Combined with Antibiotics against Drug-resistant E.coli[J]. , 2015, 42(11): 3080-3086.

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Study on the Anti-bacterial Effects of Aqueous Extract of Radix Paeoniae Rubra Combined with Antibiotics against Drug-resistant E.coli

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