低氧分压通过低氧诱导因子(HIF)影响卵母细胞的体外成熟和早期胚胎的发育

doi:10.16431/j.cnki.1671-7236.2015.06.035

Abstract

Abstract: Oocytes and early embryo in vitro culture (IVC) was a key technology of mammalian embryo engineering and was the basis of biotechnology such as genetically modified (GM) and cloning research.The factors,which affect the efficiency of in vitro culture for oocytes and early embryo,include the composition,ion concentration and osmotic pressure of the culture medium,and the gas composition and temperature of the culture environment. Recent studies have shown that the oxygen tension in the culture systems can significantly affect the development of embryos,and this effect is mainly regulated by the hypoxia-inducible factor (HIF). This paper reviewed the effects of the oxygen tension on oocyte maturation and early embryo development,and the structure and regulation mechanism of HIF were discussed,in order to provide a theoretical basis for further explore the application of hypoxia method in the in vitro culture of oocytes and early embryo.

Key words: HIF; oxygen tension; oocyte; early embryo

CLC Number:

S814.6

LIU Xiao-lin, DU Feng-jiao, LEI Chuan, RUAN Qiu-yan, WU Zhu-lian, SUN Hong-liang, ZHAO Xin, DENG Yan-fei, LU Feng-hua, SHI De-shun. Effects of Low Oxygen Tension for in vitro Oocyte Maturation and Early Embryo Development through Hypoxia-inducible Factor (HIF)[J]. , 2015, 42(6): 1559-1565.

References

[1] Bavister B D.Culture of preimplantation embryos:Facts and artifacts[J].Human Reproduction Update,1995,1:91-148.

[2] Plendl J.Angiogenesis and vascular regression in the ovary[J].Anatomia Histologia Embryologia,2000,29:257-266.

[3] Tamanini C,De Ambrogi M.Angiogenesis in developing follicle and corpus luteum[J].Reproduction in Domestic Animals,2004,39:206-216.

[4] Banwell K M.Oxygen concentration during oocyte maturation in the mouse[D].Adelaide:The University of Adelaide,2009.

[5] Huey S,Abuhamad A,Barroso G,et al.Perifollicular blood flow Doppler indices,but not follicular P_O₂,P_CO₂,or pH,predict oocyte developmental competence in in vitro fertilization[J].Fertility and Sterility,1999,72:707-712.

[6] Van Blerkom J,Antczak M,Schrader R.The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid:Association with vascular endothelial growth factor levels and perifollicular blood flow characteristics[J].Human Reproduction,1997,12:1047-1055.

[7] Bronson R.The male factor in recurrent pregnancy loss and embryo implantation failure[A].Recurrent Pregnancy Loss:Causes,Controversies,and Treatment[C].2014.

[8] Fujii J,Tsunoda S,Kimura N.Antithetical roles of reactive oxygen species in mammalian reproduction[A].Systems Biology of Free Radicals and Antioxidants[C].2014.

[9] Johnson M H,Nasresfahani M H.Radical solutions and cultural problems:Could free oxygen radicals be responsible for the impaired development of preimplantation mammalian embryos in vitro[J].Bioessays,1994,16:31-38.

[10] Khalil W A,Marei W F,Khalid M.Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development[J].Theriogenology,2013,80:161-168.

[11] Kitagawa Y,Suzuki K,Yoneda A,et al.Effects of oxygen concentration and antioxidants on the in vitro developmental ability,production of reactive oxygen species (ROS),and DNA fragmentation in porcine embryos[J].Theriogenology,2004,62:1186-1197.

[12] You J,Kim J,Lim J,et al.Anthocyanin stimulates in vitro development of cloned pig embryos by increasing the intracellular glutathione level and inhibiting reactive oxygen species[J].Theriogenology,2010,74:777-785.

[13] Arias M E,Sanchez R,Felmer R.Evaluation of different culture systems with low oxygen tension on the development,quality and oxidative stress-related genes of bovine embryos produced in vitro[J].Zygote,2012,20:209-217.

[14] Bermejo-Alvarez P,Lonergan P,Rizos D,et al.Low oxygen tension during IVM improves bovine oocyte competence and enhances anaerobic glycolysis[J].Reproductive Biomedicine Online,2010,20:341-349.

[15] Hashimoto S,Minami N,Takakura R,et al.Low oxygen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cumulus-oocyte complexes[J].Molecular Reproduction and Development,2000,57:353-360.

[16] Park J,Hong J,Yong H,et al.High oxygen tension during in vitro oocyte maturation improves in vitro development of porcine oocytes after fertilization[J].Animal Reproduction Science,2005,87:133-141.

[17] Hirao Y,Shimizu M,Iga K,et al.Optimization of oxygen concentration for growing bovine oocytes in vitro:Constant low and high oxygen concentrations compromise the yield of fully grown oocytes[J].Journal of Reproduction and Development,2012,58:204-211.

[18] Kang J T,Kwon D K,Park S J,et al.Quercetin improves the in vitro development of porcine oocytes by decreasing reactive oxygen species levels[J].Journal of Veterinary Science,2013,14:15-20.

[19] Kang J T,Atikuzzaman M,Kwon D K,et al.Developmental competence of porcine oocytes after in vitro maturation and in vitro culture under different oxygen concentrations[J].Zygote,2012,20:1-8.

[20] Kikuchi K,Onishi A,Kashiwazaki N,et al.Successful piglet production after transfer of blastocysts produced by a modified in vitro system[J].Biology of Reproduction,2002,66:1033-1041.

[21] Marques M,de Barros F,Goissis M,et al.Effect of low oxygen tension atmosphere and maturation media supplementation on nuclear maturation,cortical granules migration and sperm penetration in swine in vitro fertilization[J].Reproduction in Domestic Animals,2012,47:491-497.

[22] Banwell K,Lane M,Russell D,et al.Oxygen concentration during mouse oocyte in vitro maturation affects embryo and fetal development[J].Human Reproduction,2007,22:2768-2775.

[23] Rodrigues B,Rodrigues C,Salviano M,et al.Similar patterns of embryo development in canine oocytes cultured in vitro at oxygen tensions of 5% and 20%[J].Theriogenology,2013,79:1224-1228.

[24] Im G S,Lai L,Liu Z,et al.In vitro development of preimplantation porcine nuclear transfer embryos cultured in different media and gas atmospheres[J].Theriogenology,2004,61:1125-1135.

[25] Alam H,Weck J,Maizels E,et al.Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone[J].Endocrinology,2009,150:915-928.

[26] Donaubauer E,Hunzicker-Dunn M.Hypoxia and FSH enhances HIF1 activity in rat granulosa cells[J].Biology of Reproduction,2011,85:751.

[27] Rico C,Dodelet-Devillers A,Paquet M,et al.HIF1 activity in granulosa cells is required for FSH-regulated vegfa expression and follicle survival in mice 1[J].Biology of Reproduction,2014,90(6):135.

[28] Goldberg M A,Dunning S P,Bunn H F.Regulation of the erythropoietin gene:Evidence that the oxygen sensor is a heme protein[J].Science,1988,242:1412-1415.

[29] Ke Q,Costa M.Hypoxia-inducible factor-1 (HIF-1)[J].Molecular Pharmacology,2006,70:1469-1480.

[30] Semenza G L,Nejfelt M K,Chi S M,et al.Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene[J].Proceedings of the National Academy of Sciences,1991,88:5680-5684.

[31] Dunwoodie S L.The role of hypoxia in development of the mammalian embryo[J].Developmental Cell,2009,17:755-773.

[32] Adams J,Difazio L,Rolandelli R,et al.HIF-1:A key mediator in hypoxia (review)[J].Acta Physiologica Hungarica,2009,96:19-28.

[33] Bárdos J I,Ashcroft M.Negative and positive regulation of HIF-1:A complex network[J].Biochimica et Biophysica Acta (BBA)-Reviews on Cancer,2005,1755:107-120.

[34] Hellwig-Bürgel T,Stiehl D P,Wagner A E,et al.Review:Hypoxia-inducible factor-1 (HIF-1):A novel transcription factor in immune reactions[J].Journal of Interferon & Cytokine Research,2005,25(6):297-310.

[35] Pugh C W,O'Rourke J F,Nagao M,et al.Activation of hypoxia-inducible factor-1:Definition of regulatory domains within the α subunit[J].Journal of Biological Chemistry,1997,272:11205-11214.

[36] Ranasinghe W K,Baldwin G S,Shulkes A,et al.Normoxic regulation of HIF-1 [alpha] in prostate cancer[J].Nature Reviews Urology,2014,11:419-425.

[37] Denko N C.Hypoxia,HIF1 and glucose metabolism in the solid tumour[J].Nature Reviews Cancer,2008,8:705-713.

[38] Na Y R,Han K C,Park H,et al.Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300[J].Biochemical and Biophysical Research Communications,2013,434:879-884.

[39] Bartrons R,Caro J.Hypoxia,glucose metabolism and the Warburg's effect[J].Journal of Bioenergetics and Biomembranes,2007,39:223-229.

[40] Yoon J,Juhn K M,Ko J K,et al.Effects of oxygen tension and IGF-Ⅰ on HIF-1α protein expression in mouse blastocysts[J].Journal of Assisted Reproduction and Genetics,2013,30:99-105.

[41] Zhang Z,Yin D,Wang Z.Contribution of hypoxia-inducible factor-1α to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells[J].Animal Science Journal,2011,82:244-250.

[42] Jiang Y F,Tsui K H,Wang P H,et al.Hypoxia regulates cell proliferation and steroidogenesis through protein kinase A signaling in bovine corpus luteum[J].Animal Reproduction Science,2011,129:152-161.

[43] Tam K K,Russell D L,Peet D J,et al.Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity[J].Molecular and Cellular Endocrinology,2010,327:47-55.

[44] Nishimura R,Okuda K.Hypoxia is important for establishing vascularization during corpus luteum formation in cattle[J].Journal of Reproduction and Development,2010,56:110-116.

[45] Nishimura R,Sakumoto R,Tatsukawa Y,et al.Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum[J].Endocrinology,2006,147:4273-4280.

[46] Fadhillah S Y,Nishimura R,Okuda K.Hypoxia promotes progesterone synthesis during luteinization in bovine granulosa cells[J].The Journal of Reproduction and Development,2014,60:194.

[47] Fraisl P,Mazzone M,Schmidt T,et al.Regulation of angiogenesis by oxygen and metabolism[J].Developmental Cell,2009,16:167-179.

[48] Simon M C,Keith B.The role of oxygen availability in embryonic development and stem cell function[J].Nature Reviews Molecular Cell Biology,2008,9:285-296.

Effects of Low Oxygen Tension for in vitro Oocyte Maturation and Early Embryo Development through Hypoxia-inducible Factor (HIF)

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