包衣技术提高药物药学性能的研究进展

doi:10.16431/j.cnki.1671-7236.2018.11.035

摘要/Abstract

摘要：

兽药对畜牧生产中的疾病防控和健康养殖意义重大，但由于某些药物味苦、对胃黏膜刺激性大、稳定性差和药理作用部位靶向性差等限制了其在临床上的使用。包衣技术在改善药物适口性、提高药物稳定性和实现药物控缓释和靶向性等方面具有显著优势。作者总结了国内外关于包衣技术在改善药物适口性、提高药物稳定性、制备控缓释剂型和高效靶向释药剂型方面的研究进展，分析了包衣膜的形成原理，剖析了几种常见包衣技术的优缺点和其产业化面临的挑战，在此基础上展望了包衣技术在兽药领域的应用前景，以期为基于包衣技术的兽药新制剂的开发提供新思路。

关键词: 包衣技术; 药物; 适口性; 控缓释; 靶向

Abstract:

Veterinary medicine is of great significance in the prevention and control of diseases and healthy breeding in animal husbandry production.However,it is limited in clinical use due to poor palatability,large irritation to gastric mucosa,poor stability,and poor targeting of infection sites of certain drugs.Coating technology has significant advantages in improving drug palatability,improving drug stability and preparing controlled release and targeted dosage forms.This article summarizes the research progress on coating technology at home and abroad to improve drug palatability,improve drug stability,preparation of control and sustained-release formulations and efficient targeted drug delivery,analyzes the principle of the formation of coating film,the advantages and disadvantages of several common coating technologies and the challenges faced by their industrialization and looks forward to the application of coating technology in the field of veterinary medicine,it is respected to provide new ideas for the development of veterinary drug formulations based on coating technologies.

Key words: coating technologies; drug; palatability; controlled release; target

中图分类号:

S859

李超, 罗万和, 周凯翔, 陈冬梅, 潘源虎, 陶燕飞, 谢书宇. 包衣技术提高药物药学性能的研究进展[J]. 《中国畜牧兽医》, 2018, 45(11): 3271-3278.

LI Chao, LUO Wanhe, ZHOU Kaixiang, CHEN Dongmei, PAN Yuanhu, TAO Yanfei, XIE Shuyu. Research Progress on Coating Technologies to Improve Pharmaceutical Pharmacy Performance[J]. , 2018, 45(11): 3271-3278.

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