肯塔基沙门菌对氟喹诺酮和碳青霉烯类药物耐药性研究进展

doi:10.16431/j.cnki.1671-7236.2020.11.038

摘要/Abstract

摘要： 肯塔基沙门菌（Salmonella Kentucky）是继鼠伤寒沙门菌和肠炎沙门菌后又一与人类肠道疾病相关的沙门菌血清型，因其获得和传播耐药性的能力较强而逐渐引起关注。该血清型沙门菌按照多位点序列分型分得的众多亚型中，ST198血清亚型具有易获得耐药突变的基因组岛的特性，21世纪以来不断进化，除获得常见抗菌药物耐药基因外，还相继获得对氟喹诺酮类和碳青霉烯类药物的耐药性并扩散全球，造成临床上难以治疗的病例而引起世界卫生组织的关注。作者整理了肯塔基沙门菌的进化历程，着重阐述肯塔基沙门菌关于氟喹诺酮类及碳青霉烯类药物的耐药情况及耐药机制，以期为中国沙门菌的实验室防控监测系统提供理论依据。

关键词: 肯塔基沙门菌; 碳青霉烯酶; 耐药决定区

Abstract: Salmonella Kentucky is another Salmonella serotype associated with human intestinal diseases following Salmonella Typhimurium and Salmonella Enteritidis.It is gradually attracting attention because of its strong ability to acquire and spread drug resistance.Among the many subserotypes of this serotype divided according to the sequence of multiple loci,ST198 subserotype has the characteristics of genomic islands that are easy to obtain drug resistance mutations,and has been evolving since the 21st century.In addition,resistance to fluoroquinolones and carbapenems have been acquired and spread worldwide,causing clinically difficult cases and the concern of the World Health Organization.This article summarizes the evolution of Salmonella Kentucky and highlights the resistance status and mechanism of Salmonella Kentucky with regard to fluoroquinolones and carbapenems,so as to provide a theoretical basis for the laboratory control and monitoring system of Salmonella in China.

Key words: Salmonella Kentucky; carbapenemase; drug resistance determination zone

中图分类号:

S852.61

张靖菊, 刘静, 徐飞. 肯塔基沙门菌对氟喹诺酮和碳青霉烯类药物耐药性研究进展[J]. 中国畜牧兽医, 2020, 47(11): 3739-3748.

ZHANG Jingju, LIU Jing, XU Fei. Research Progress on Resistance of Salmonella Kentucky to Fluoroquinolones and Carbapenems[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(11): 3739-3748.

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