黄酮类化合物调控Keap1-Nrf2/ARE信号通路的抗氧化机制及其在畜禽生产中应用的研究进展

doi:10.16431/j.cnki.1671-7236.2024.07.014

摘要/Abstract

摘要： 黄酮类化合物属于多酚类化合物,广泛存在于天然植物中,具备很强的抗氧化能力。近年来,越来越多的研究证明黄酮类化合物作为饲料添加剂有益于畜牧生产。Kelch样环氧氯丙烷相关蛋白1-核因子E2相关因子2/抗氧化反应元件(Keap1-Nrf2/ARE)是增强机体抗氧化能力的关键信号通路,参与抵抗外界氧化应激。黄酮类化合物主要通过调控Keap1-Nrf2/ARE通路,激活上下游关键因子,提高抗氧化酶的活性,提高机体抗氧化能力,从而改善畜禽生长性能、繁殖性能和机体免疫力。作者通过综述Keap1-Nrf2/ARE分子结构和发挥抗氧化作用的机制,以及黄酮类化合物调控Keap1-Nrf2/ARE信号通路及其在畜禽生产中的应用研究,旨在为黄酮类化合物作为饲料添加剂的进一步开发和应用提供参考。

Abstract: Flavonoids are polyphenolic compounds that are widely found in natural plants and have strong antioxidant capabilities.In recent years,more and more studies have proved that flavonoids are beneficial to livestock production as feed additives.Kelch-like ECH-associating protein 1-nuclear factor erythroid 2 related factor 2/antioxidant response element (Keap1-Nrf2/ARE) is a key signaling pathway that enhances the body’s antioxidant capacity and is involved in resisting damage from external oxidative stress.Flavonoids mainly regulate the Keap1-Nrf2/ARE pathway,activate the expression of upstream and downstream key factors,activate the activity of antioxidant enzymes,improve the body’s antioxidant capacity,and thus achieve the improvement of animal growth performance,reproductive performance,and immune system.In this article the molecular structure of Keap1-Nrf2/ARE and its antioxidant mechanism,as well as the regulation of Keap1-Nrf2/ARE signaling pathway by flavonoids and their application in animal production were reviewed.The aim of this paper is to provide reference for the further development and application of flavonoids as feed additives.

Key words: Kelch-like ECH-associating protein 1 (Keap1); nuclear factor erythroid 2 related factor 2 (Nrf2); flavonoids; antioxidant mechanism

中图分类号:

S816.7

鄂晓迪, 赵晓南, 赵金标, 胡友军. 黄酮类化合物调控Keap1-Nrf2/ARE信号通路的抗氧化机制及其在畜禽生产中应用的研究进展[J]. 中国畜牧兽医, 2024, 51(7): 2880-2889.

E Xiaodi, ZHAO Xiaonan, ZHAO Jinbiao, HU Youjun. Research Progress on Antioxidant Mechanism of Flavonoids Regulating the Keap1-Nrf2/ARE Signaling Pathway and Its Application in Livestock and Poultry[J]. China Animal Husbandry and Veterinary Medicine, 2024, 51(7): 2880-2889.

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