止咳平喘颗粒的祛痰、镇咳及平喘作用研究

中国畜牧兽医

止咳平喘颗粒的祛痰、镇咳及平喘作用研究

程龙，辛蕊华，罗永江，王贵波，罗超应，谢家声，李锦宇，郑继方

（中国农业科学院兰州畜牧与兽药研究所，甘肃省中兽药工程技术研究中心，农业部兽用药物创制重点实验室，甘肃省新兽药工程重点实验室，甘肃兰州 730050）

收稿日期:2013-11-25 出版日期:2014-05-20 发布日期:2014-06-25
通讯作者: 郑继方，男，四川人，研究员，研究方向：中兽医学。E-mail: zhengjifang100@126.com；Tel: 0931-2115255
作者简介:程龙（1989—），男，甘肃人，硕士生，研究方向：中兽医药学。
基金资助:
“十二五”国家科技支撑计划项目（2011BAD34B03）；甘肃省科技支撑计划项目（1304NKCA155）；公益性行业科研专项经费（201303040-18）。

Study on the Effects of Zhike Pingchuan Granules on Expectorant, Antitussive and Antiasthmatic

CHENG Long, XIN Rui-hua, LUO Yong-jiang, WANG Gui-bo, LUO Chao-ying, XIE Jia-sheng, LI Jin-yu, ZHENG Ji-fang

（Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Engineering ＆ Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China）

Received:2013-11-25 Online:2014-05-20 Published:2014-06-25

摘要/Abstract

摘要： 试验旨在通过动物试验观察止咳平喘颗粒的祛痰、镇咳及平喘药理作用。采用毛细玻管法观察其祛痰作用；采用浓氨水引咳法观察其止咳作用；采用喷雾致喘法观察其平喘作用。结果显示，止咳平喘颗粒低剂量组增加的痰液分泌量与空白对照组相比差异显著（P＜0.05）,中、高剂量组增加的痰液分泌量与空白对照组相比均差异极显著（P＜0.01）；止咳平喘颗粒高、中、低剂量组对于延长咳嗽潜伏期和减少咳嗽次数与空白对照组相比均差异极显著（P＜0.01）；止咳平喘颗粒低剂量组延长4%氯化乙酰胆碱引喘豚鼠的潜伏期与空白对照组相比差异不显著（P＞0.05），高、中剂量组延长4%氯化乙酰胆碱引喘豚鼠的潜伏期与空白对照组相比均差异极显著（P＜0.01）。结果表明止咳平喘颗粒具有祛痰、镇咳及平喘作用。

关键词:

止咳平喘颗粒; 祛痰; 镇咳; 平喘

Abstract: The assay was aimed to investigate the effects of Zhike Pingchuan granules on expectorant, antitussive and antiasthmatic by animals experiment.Capillary method was used to observe the expectorant effect in rat,the cough model induced by strong ammonia in mice was used to observe the antitussive effect,asthma model induced by spraying method was used to observe the antiasthmatic effect.The results showed that the low dosage group of Zhike Pingchuan granules significantly increased excretion of trachea quantity compared with the blank control group (P＜0.05),and there were extremely significant differences between the blank control group and middle,high dosage groups (P＜0.01);the three high,middle and low dosage groups of Zhike Pingchuan granules extremely significantly prolonged the latent period of cough and decreased the frequency of cough induced by strong ammonia compared with the blank control group (P＜0.01); the low dosage group of Zhike Pingchuan granules had not significantly prolonged the latent period of asthma induced by 4% acetylcholine chloride compared with the blank control group (P＞0.05),and middle and high dosage groups had extremely significant difference compared with the blank control group (P＜0.01).Zhike Pingchuan granules had the effects of expectorant,antitussive and antiasthmatic.

Key words: Zhike Pingchuan granules; expectorant; antitussive; antiasthmatic

程龙，辛蕊华，罗永江，王贵波，罗超应，谢家声，李锦宇，郑继方. 止咳平喘颗粒的祛痰、镇咳及平喘作用研究 [J]. 中国畜牧兽医.

CHENG Long, XIN Rui-hua, LUO Yong-jiang, WANG Gui-bo, LUO Chao-ying, XIE Jia-sheng, LI Jin-yu, ZHENG Ji-fang. Study on the Effects of Zhike Pingchuan Granules on Expectorant, Antitussive and Antiasthmatic[J]. .