外源性硫化氢对骨骼肌疲劳的影响

中国畜牧兽医

外源性硫化氢对骨骼肌疲劳的影响

孙洪兆¹，赵术珍²，鲁凯¹，侯丰田¹，韩佳秀¹，赵鹏飞¹，张兴梅¹，张丽¹，张雪¹，韩增晓¹，刘晴晴¹，刘雪联¹

（1.齐鲁师范学院生物系，山东济南 250013；2.山东省农业科学院高新技术研究中心，山东济南 250100）

出版日期:2014-01-20 发布日期:2014-02-27
作者简介:孙洪兆（1978—），男，山东人，博士，硕士生导师，副教授，研究方向：动物生理。
基金资助:
山东省自然科学青年基金（ZR2011CL012）；山东省高等学校科技计划项目（J11LC17）。

Effect of Exogenous Hydrogen Sulfide on Skeletal Muscular Fatigue

SUN Hong-zhao¹,ZHAO Shu-zhen²，LU Kai¹，HOU Feng-tian¹，HAN Jia-xiu¹，ZHAO Peng-fei¹，ZHANG Xing-mei¹,ZHANG Li¹,ZHANG Xue¹,HAN Zeng-xiao¹,LIU Qing-qing¹,LIU Xue-lian¹

(1. Biological Department, Qi Lu Normal University, Jinan 250013, China；2. High-Tech Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China)

Online:2014-01-20 Published:2014-02-27

摘要/Abstract

摘要： 试验旨在探讨硫化氢供体硫氢化钠改善疲劳状态下肌力减退的作用。采用脉冲式电流直接刺激腓肠肌作为疲劳模型，对比硫氢化钠和任氏液分别对蟾蜍腓肠肌疲劳的影响。结果表明，硫氢化钠在浓度为5×10^-4、1×10^-3、2×10^-3 mol/L时，离体腓肠肌达到最大收缩幅度90%、50%和10%的时间极显著长于在任氏液作用下的离体腓肠肌(P<0.01)；5.6 mg/kg硫氢化钠也极显著延长了在体腓肠肌达到最大收缩幅度90%、50%和10%的时间(P <0.01)。表明外源性硫化氢具有延缓肌肉疲劳的作用。

关键词: 硫氢化钠; 蟾蜍腓肠肌; 肌肉疲劳

Abstract: To investigate the effects of NaHS, an exogenous hydrogen sulfide donor, on skeletal muscular fatigue. Toad gastrocnemius was stimulated by pulse electric curent. The results showed that NaHS at concentrations of 5×10^-4 mol/L (in vitro, P < 0.01), 1×10^-3 mol/L (in vitro, P < 0.01), 2×10^-3 mol/L (in vitro, P < 0.01) and 5.6 mg/(kg·BW) (in vivo, P < 0.01) could prolong the time of contraction amplitude decreasing to 90%, 50% and 10% of the maximum contraction amplitude. The study showed that exogenous hydrogen sulfide had effect on antifatigue.

Key words: sodium hydrosulfide; toad gastrocnemius; muscular fatigue

孙洪兆，赵术珍，鲁凯，侯丰田，韩佳秀，赵鹏飞，张兴梅，张丽，张雪，韩增晓，刘晴晴，刘雪联. 外源性硫化氢对骨骼肌疲劳的影响[J]. 中国畜牧兽医.

SUN Hong-zhao，ZHAO Shu-zhen，LU Kai1，HOU Feng-tian1，HAN Jia-xiu1，ZHAO Peng-fei，ZHANG Xing-mei,ZHANG Li,ZHANG Xue,HAN Zeng-xiao,LIU Qing-qing,LIU Xue-lian. Effect of Exogenous Hydrogen Sulfide on Skeletal Muscular Fatigue[J]. China Animal Husbandry & Veterinary Medicine.

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