甲状旁腺激素对骨代谢相关基因调控的研究进展

›› 2013, Vol. 40 ›› Issue (3): 141-145.

甲状旁腺激素对骨代谢相关基因调控的研究进展

邓华¹, 初晓辉², 殷红³, 陈小波¹, 徐志强⁴, 谷大海⁴, 樊月圆¹, 葛长荣¹, 贾俊静¹, 廖国周⁴, 荣华¹

1. 云南农业大学动物科学技术学院,云南省动物营养与饲料科学重点实验室,云南昆明 650201;
2. 云南农业大学人事处,云南昆明 650201;
3. 云南省动植物检疫局,云南昆明 650041;
4. 云南农业大学食品科学技术学院,云南昆明 650201

收稿日期:2012-09-27 出版日期:2013-03-20 发布日期:2013-03-19
通讯作者: 荣华(1986-),男,湖北人,硕士,助教,主要从事动物科学研究。E-mail:ronghua1986.1234@yahoo.com.cn E-mail:ronghua1986.1234@yahoo.com.cn
作者简介:邓华(1986-),女,云南人,硕士生,研究方向:畜产品品质和安全。
基金资助:
NSFC-云南联合基金项目:红骨山羊骨骼矿物质元素代谢机制研究(U0836601);云南省农业厅保种经费;云南省中青年学术带头人后备人才(2008PY043)。

Research Progress on the Expression of Parathyroid Hormone to Regulate Bone Metabolism Related Genes

DENG Hua¹, CHU Xiao-hui², YIN Hong³, CHEN Xiao-bo¹, XU Zhi-qiang⁴, GU Da-hai⁴, FAN Yue-yuan¹, GE Chang-rong¹, JIA Jun-jing¹, LIAO Guo-zhou⁴, RONG Hua¹

1. Yunnan Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China;
2. Department of Personnel, Yunnan Agricultural University, Kunming 650201, China;
3. Animal and Plant Inspection and Quarantine Bureau in Yunnan Province, Kunming 650041, China;
4. College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China

Received:2012-09-27 Online:2013-03-20 Published:2013-03-19

摘要/Abstract

摘要： 骨代谢包括骨形成和骨吸收两个过程。甲状旁腺激素是骨形成和骨重建过程中一个重要的调节因子,甲状旁腺激素通过G蛋白偶联受体、甲状旁腺激素/甲状旁腺激素相关肽受体的活动调节骨代谢。近年来甲状旁腺激素显著的临床效果,为骨骼合成代谢药物在骨质疏松症的治疗上开辟了一个新时代。作者主要综述了甲状旁腺激素在骨代谢中的作用机制及相关调控基因的作用。

关键词: 甲状旁腺激素; 骨形成; 骨吸收; 骨代谢

Abstract: Bone metabolism included bone formation and bone absorption. Parathyroid hormone(PTH) was a factor and played an important role in regulating bone remodeling and formation,in where PHT through the G protein coupled receptors,parathyroid hormone/parathyroid hormone related peptide receptor activity regulating bone metabolism. Recent years, PTH had now been approved for clinical diagnose in the treatment of bone loss in osteoporosis as bone anabolic drugs and opened up a new age. The author summarized the mechanism of PTH on the bone remodeling and function of related regulatory genes in bone metabolism.

Key words: parathyroid hormone; bone formation; bone resorption; bone metabolism

中图分类号:

Q573

邓华, 初晓辉, 殷红, 陈小波, 徐志强, 谷大海, 樊月圆, 葛长荣, 贾俊静, 廖国周, 荣华. 甲状旁腺激素对骨代谢相关基因调控的研究进展[J]. , 2013, 40(3): 141-145.

DENG Hua, CHU Xiao-hui, YIN Hong, CHEN Xiao-bo, XU Zhi-qiang, GU Da-hai, FAN Yue-yuan, GE Chang-rong, JIA Jun-jing, LIAO Guo-zhou, RONG Hua. Research Progress on the Expression of Parathyroid Hormone to Regulate Bone Metabolism Related Genes[J]. China Animal Husbandry & Veterinary Medicine, 2013, 40(3): 141-145.

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