糖原合成激酶抑制剂在胚胎干细胞自我更新中的作用

摘要/Abstract

摘要： 胚胎干细胞(embryonic stem cells,ES)是从早期囊胚内细胞团分离培养出来的能够不断维持自我更新和具有发育多能性的细胞。Wnt信号通路在维持胚胎干细胞的自我更新方面起着重要作用,糖原合成激酶 (glycogen synthase kinase-3,GSK-3)抑制剂可以激活Wnt信号通路,促进胚胎干细胞自我更新和增强细胞间连接。作者就GSK-3抑制剂在胚胎干细胞自我更新、细胞连接方面的作用及其作用机制进行简单综述。

关键词: 胚胎干细胞; Wnt; 糖原合成激酶; 6-bromoindirubin-3’-oxime; CHIR99021

Abstract: Embryonic stem (ES) cells are derived from the inner cell mass of early blastocyst, and possess the ability of self-renewal and maintenance pluripotency. Wnt signaling pathway plays important roles in maintaining self-renewal of ES cells. Glycogen synthase kinase-3 (GSK-3) inhibitors can active Wnt signaling pathway,then promote the self-renewal and cell-to-cell adhesion of ES cells. In this paper, we take a review for the effect and mechanism of GSK-3 inhibitors on maintaining self-renewal and cell-to-cell adhesion of ES cells.

Key words: embryonic stem cells; Wnt; glycogen synthase kinase-3; 6-bromoindirubin-3’-oxime; CHIR99021

中图分类号:

Q813.7

劳艳萍, 柯浩, 孙洪亮, 刘荣立, 马玉洁, 阮秋燕, 雷钏, 陆凤花, 李湘萍, 石德顺. 糖原合成激酶抑制剂在胚胎干细胞自我更新中的作用[J]. , 2013, 40(10): 134-139.

LAO Yan-ping, KE Hao, SUN Hong-liang, LIU Rong-li, MA Yu-jie, RUAN Qiu-yan, LEI Chuan, LU Feng-hua, LI Xiang-ping, SHI De-shun. Effect of Glycogen Synthase Kinase-3 Inhibitor on Maintaining Self-Renewal of Embryonic Stem Cells[J]. , 2013, 40(10): 134-139.

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