肠出血性大肠杆菌Ⅲ型分泌系统调控因素的研究进展

›› 2012, Vol. 39 ›› Issue (6): 161-164.

肠出血性大肠杆菌Ⅲ型分泌系统调控因素的研究进展

魏波^1,2, 刘明强¹, 呼和巴特尔¹

1. 内蒙古农业大学兽医学院,内蒙古呼和浩特 010018;
2. 中国人民解放军军事医学科学院,北京 100071

修回日期:2011-11-09 出版日期:2012-06-20 发布日期:2012-07-02
通讯作者: 呼和巴特尔,男,内蒙古人,博士生导师,教授,研究方向:寄生虫病及防治。E-mail:hhbte@yahoo.com.cn E-mail:hhbte@yahoo.com.cn
作者简介:魏波(1984－),女,山东人,博士生,研究方向:预防兽医学。
基金资助:
国家自然基金(C40620610)。

Development of Regulation Factor of Type Ⅲ Secretion Systems in Enterohaemorrhagic Escherichia coli

WEI Bo^1,2, LIU Ming-qiang¹, HUHE Baterer¹

1. College of Animal Science and Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China;
2. Institute of Biotechnology, Academy of Military Medical Sciences of PLA, Beijing 100071, China

Revised:2011-11-09 Online:2012-06-20 Published:2012-07-02

摘要/Abstract

摘要： Ⅲ型分泌系统(Typr Ⅲ secretion system,T3SS)是一种将细菌蛋白通过膜屏障注入宿主细胞的装置,Ⅲ型分泌系统(T3SS)是肠出血性大肠杆菌定植反刍动物储存宿主所必需的,也是引起人致病的重要原因之一。E. coli 注射蛋白质进入上皮细胞使得细菌可以黏附并且促使其长时间定植在动物体内。在此,对关于EHEC Ⅲ型分泌系统调控的研究近况、效应蛋白表达的共调控进行了综述。

关键词: 肠出血性大肠杆菌; Ⅲ型分泌系统; 效应蛋白

Abstract: Type Ⅲ secretion systems (T3SS) enable the injection of bacterial proteins through membrane barriers into host cells. This system is required for colonization of their ruminant reservoir hosts by enterohaemorrhagic Escherichia coli (EHEC) and might also be important for the etiology of disease in the incidental human host. T3SS of E. coli inject a cocktail of proteins into epithelial cells that enable bacterial attachment and promotes longer-term colonization in the animal. Here, we review recent progress in our understanding of the regulation of T3SS in EHEC, focusing on the induction and assembly of the T3SS, and the co-ordination of effector protein expression.

Key words: enterohaemorrhagic Escherichia coli; type Ⅲ secretion systems; effector protein

中图分类号:

S852.61

魏波, 刘明强, 呼和巴特尔. 肠出血性大肠杆菌Ⅲ型分泌系统调控因素的研究进展[J]. , 2012, 39(6): 161-164.

WEI Bo, LIU Ming-qiang, HUHE Baterer. Development of Regulation Factor of Type Ⅲ Secretion Systems in Enterohaemorrhagic Escherichia coli[J]. , 2012, 39(6): 161-164.

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